{"id":"W2955997569","doi":"10.1093/jjco/hyz085","title":"An umbrella study of biomarker-driven targeted therapy in patients with platinum-resistant recurrent ovarian cancer: a Korean Gynecologic Oncology Group study (KGOG 3045), AMBITION","year":2019,"lang":"en","type":"article","venue":"Japanese Journal of Clinical Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Medicine; Durvalumab; Olaparib; Oncology; Gynecologic oncology; Internal medicine; Clinical endpoint; Ovarian cancer; Biomarker; Response Evaluation Criteria in Solid Tumors; Immunotherapy; Chemotherapy; Targeted therapy; Clinical trial; Cancer; Nivolumab; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004017949,0.0003419855,0.0024719,0.0004692086,0.00006574314,0.00001158867,0.0003852155,0.0004091102,0.0006214491],"category_scores_gemma":[0.0004001762,0.0002314925,0.0002236832,0.0006758648,0.0002513015,0.0002393901,0.00005168486,0.001099436,0.000008541925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008233502,"about_ca_system_score_gemma":0.0009516986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003861338,"about_ca_topic_score_gemma":0.002022102,"domain_scores_codex":[0.9914491,0.003103103,0.003577595,0.0005738979,0.0008536805,0.000442592],"domain_scores_gemma":[0.9930246,0.001893394,0.003160995,0.0005356348,0.0009879549,0.0003973671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08010507,0.05515864,0.8028031,0.00001999939,0.0006643853,0.0002550157,0.004327588,0.0001681188,0.004383897,0.000006228831,0.00005736414,0.05205058],"study_design_scores_gemma":[0.0727916,0.2477889,0.6743348,0.00009358212,0.0001347094,0.00002416142,0.004179677,0.000118444,0.00003116315,0.00003226994,0.000309679,0.0001609579],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949992,0.00007118188,0.000007679092,0.0005768729,0.001026251,0.002982591,0.000013011,0.00002365637,0.0002996058],"genre_scores_gemma":[0.9982203,0.0001472643,0.0006035194,0.0006105143,0.000249885,0.00009859768,0.00001877388,0.00004008995,0.0000110206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1926303,"threshold_uncertainty_score":0.9439992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0878502810883729,"score_gpt":0.4397574802038167,"score_spread":0.3519071991154438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}