{"id":"W2956058071","doi":"10.1158/1538-7445.am2019-3808","title":"Abstract 3808: 225Ac-CD33 Radioimmunotherapy potently increases the sensitivity of resistant acute myeloid leukemia lines to the Bcl-2 inhibitor venetoclax by mediating a reduction in cellular Mcl-1 levels","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Venetoclax; Cytarabine; Medicine; Myeloid leukemia; CD33; Azacitidine; Leukemia; Myeloid; Internal medicine; Oncology; Cancer research; Immunology; Chronic lymphocytic leukemia; Stem cell; Chemistry; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006952933,0.0003032219,0.0002240345,0.0002321897,0.0001170381,0.0001932244,0.0001830172,0.0002174789,0.005816981],"category_scores_gemma":[0.00005328051,0.00008464541,0.0001689624,0.0001602743,0.0001265879,0.0001241013,0.0001169792,0.0007382365,0.0008969055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310366,"about_ca_system_score_gemma":0.0001645262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009431824,"about_ca_topic_score_gemma":0.0007680298,"domain_scores_codex":[0.9999197,0.00001394737,0.000004572757,0.00001392788,0.00002102632,0.00002701265],"domain_scores_gemma":[0.999962,0.000005549753,0.000007439718,0.000005673122,0.000004971689,0.00001436819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000747629,0.0004191358,0.0002176379,0.00005532964,0.00001488274,0.00004004653,0.0000205283,0.0002456267,0.9875814,0.0002560916,0.001142462,0.009259365],"study_design_scores_gemma":[0.0001727298,0.004829549,0.003633283,0.000009332625,0.00003415439,0.0002771747,0.00002160448,0.001203545,0.9800197,0.00007028896,0.009721788,0.000006838165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881637,0.002007629,0.001609495,0.000165757,0.0001031736,0.00006776066,0.0005913046,0.0004913858,0.006799763],"genre_scores_gemma":[0.9921868,0.000609955,0.001042206,0.00006679266,0.00001641273,0.00003275749,0.000702899,0.00002423048,0.005317956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005816981,"threshold_uncertainty_score":0.01945966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05488437066301336,"score_gpt":0.3899085341727618,"score_spread":0.3350241635097484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}