{"id":"W2956069616","doi":"10.1016/j.chom.2019.06.003","title":"A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; H2020 European Research Council; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Quorum sensing; Connective tissue; Receptor; Mast cell; Immunity; Cell biology; Microbiology; Cell; Immune system; Immunology; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078311,0.0005721154,0.0002907615,0.0002998638,0.0002716416,0.0003719536,0.0005117626,0.0007487722,0.00221527],"category_scores_gemma":[0.0003045062,0.000185313,0.0004025464,0.0001568692,0.0003305483,0.0005073483,0.0004458108,0.0005380405,0.0008100291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064768,"about_ca_system_score_gemma":0.0002118084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003264149,"about_ca_topic_score_gemma":0.000385136,"domain_scores_codex":[0.9997979,0.00002598084,0.00001078891,0.00003788172,0.00004029882,0.00008709461],"domain_scores_gemma":[0.9998215,0.00003640708,0.00003672277,0.00001282682,0.00002943607,0.00006313568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001809139,0.00001617902,0.0003258793,0.00004001018,0.000004151176,0.0002689814,0.00001666368,0.00002159684,0.9975755,0.0001399398,0.00009332396,0.001316931],"study_design_scores_gemma":[0.0002172983,0.001155049,0.02907988,0.00002246606,0.00007034079,0.003645592,0.0001904737,0.002731072,0.9564222,0.0004510867,0.005985981,0.00002853248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798113,0.004721206,0.01108111,0.0003457133,0.0001852763,0.0001309355,0.0003981478,0.0001390432,0.003187291],"genre_scores_gemma":[0.9905148,0.001552681,0.003529132,0.0002113245,0.0001225588,0.00004644547,0.000495503,0.00002229864,0.003505412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00221527,"threshold_uncertainty_score":0.007410824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005131971133131547,"score_gpt":0.189289173343258,"score_spread":0.1841572022101265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}