{"id":"W2956075103","doi":"10.1073/pnas.1905558116","title":"Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Structural Genomics Consortium; Institut National de la Recherche Scientifique; University of Toronto","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Office of Science; Medical Research Council; Ministero dello Sviluppo Economico; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Fonds de recherche du Québec – Nature et technologies; Armand-Frappier Foundation; Genome Canada; Francis Crick Institute; Wellcome Trust; Ontario Genomics; GlaxoSmithKline; Eli Lilly and Company; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Pfizer; Argonne National Laboratory; U.S. Department of Energy","keywords":"Protein kinase A; Plasmodium falciparum; cGMP-dependent protein kinase; Protein structure; Allosteric regulation; Dimer; Biophysics; Protein kinase domain; Kinase; Cyclic guanosine monophosphate; Cell biology; Biology; Helix (gastropod); Enzyme activator; Biochemistry; Binding site; Chemistry; Enzyme; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001135005,0.00008228367,0.0001855145,0.0001479671,0.00007904854,0.00001251008,0.0004877246,0.00009932194,0.00002325525],"category_scores_gemma":[0.001448425,0.00004326932,0.0000820357,0.0004312644,0.0002326224,0.0002341928,0.0000895976,0.0002388572,1.68649e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005279113,"about_ca_system_score_gemma":0.0001209823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003141262,"about_ca_topic_score_gemma":4.007709e-7,"domain_scores_codex":[0.9981879,0.00001550927,0.0003046524,0.0001915206,0.001142698,0.0001577376],"domain_scores_gemma":[0.9990217,0.0001094739,0.0003912706,0.00001673108,0.0004313085,0.00002947878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662663,0.00001234928,0.006436243,0.0001323177,0.00001028426,2.92739e-9,0.00006459286,0.0000251716,0.633549,0.3595017,0.0000153343,0.00008671697],"study_design_scores_gemma":[0.0006066982,0.0001098577,0.194348,0.0001630007,0.000007330578,0.000003066782,0.00010308,0.00155546,0.6258145,0.1772525,0.000002808204,0.00003367683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849414,0.00001689473,0.000003905762,0.01288954,0.00001352944,0.001608943,0.00001583388,0.0000038456,0.0005061099],"genre_scores_gemma":[0.9979078,0.00000167327,0.001490043,0.0001677836,0.00003537182,0.00004985836,2.618534e-7,0.000003876853,0.0003432872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1879118,"threshold_uncertainty_score":0.1764472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588106552822252,"score_gpt":0.3173946582645009,"score_spread":0.2915135927362784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}