{"id":"W2956075419","doi":"10.1038/s41598-019-45704-z","title":"Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Beijing Normal University; National Natural Science Foundation of China; Salt Science Research Foundation","keywords":"Phosphatase; Dephosphorylation; Isocitrate dehydrogenase; Phosphofructokinase 2; Kinase; Enzyme; Chemistry; Bifunctional; Biochemistry; Mutant; Phosphorylation; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166436,0.0002513056,0.0002027224,0.000107883,0.00009890749,0.0002522932,0.000301572,0.0001616993,0.0007014672],"category_scores_gemma":[0.0001945657,0.00008763059,0.0001491523,0.0001348043,0.000154495,0.0001375924,0.0001464859,0.000285045,0.0001797179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263484,"about_ca_system_score_gemma":0.0001587514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000176,"about_ca_topic_score_gemma":0.0007576899,"domain_scores_codex":[0.999899,0.00001242206,0.000008615668,0.00002040532,0.00004369442,0.0000158357],"domain_scores_gemma":[0.9999311,0.00001084823,0.00001912973,0.000008020052,0.00001466455,0.00001625555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009125401,0.0000245973,0.000502484,0.00002917555,0.000005356384,0.00005495556,0.000007217165,0.0002008731,0.9981888,0.0001210086,0.0000252533,0.0007490185],"study_design_scores_gemma":[0.000008498754,0.00004870829,0.00212607,0.000001385332,0.000005948395,0.0001569713,0.00001119418,0.002241278,0.9943944,0.0000406862,0.0009613595,0.000003390719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963756,0.0003710782,0.002435396,0.00004132416,0.00001161594,0.000009272138,0.0002753579,0.00002784695,0.0004524192],"genre_scores_gemma":[0.9969372,0.0001397574,0.001859346,0.00000957447,0.000002244165,0.000008781922,0.0004180096,0.000009074042,0.0006159501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001000176,"threshold_uncertainty_score":0.002367854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00995585487185035,"score_gpt":0.2300994307176963,"score_spread":0.220143575845846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}