{"id":"W2956118764","doi":"10.1158/1538-7445.am2019-300","title":"Abstract 300: A new combination therapy to treat metastatic breast cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Vinorelbine; Eribulin; Vinca alkaloid; Olaparib; Microtubule polymerization; Cancer research; Vinca; Mechanism of action; Tubulin; Medicine; Mitosis; Pharmacology; Microtubule; Breast cancer; Cancer; Chemistry; Poly ADP ribose polymerase; Metastatic breast cancer; Biology; Polymerase; Cell biology; Chemotherapy; Internal medicine; Biochemistry; Vincristine; In vitro; DNA; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007722612,0.0002573279,0.0004282221,0.0006314865,0.0001988359,0.0003608478,0.0002769782,0.0003334479,0.007625734],"category_scores_gemma":[0.00007545904,0.00008301849,0.0002570777,0.0004453349,0.00009163152,0.0002779803,0.00025615,0.0007883812,0.003120623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021757,"about_ca_system_score_gemma":0.0001886826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003523874,"about_ca_topic_score_gemma":0.001460711,"domain_scores_codex":[0.9999536,0.00000778623,0.000003816153,0.000009448566,0.00001819328,0.000007059131],"domain_scores_gemma":[0.9999802,0.00000259242,0.000003019004,0.000001679204,0.000004776852,0.000007755562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001732092,0.001753234,0.0008701637,0.001876666,0.0001466263,0.001327026,0.0000921693,0.0006594494,0.11465,0.002543269,0.03431971,0.8400295],"study_design_scores_gemma":[0.004245176,0.01289897,0.01581814,0.0006389916,0.0006401621,0.01435283,0.0001519441,0.004545329,0.06484677,0.004806166,0.8769127,0.0001428705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4522094,0.3298152,0.01567132,0.006125498,0.003229284,0.001742477,0.004813517,0.002111027,0.1842823],"genre_scores_gemma":[0.7456666,0.1390837,0.01006094,0.004975518,0.0007110122,0.0007895861,0.004231976,0.0001683031,0.09431238],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007625734,"threshold_uncertainty_score":0.02551061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1491931179236612,"score_gpt":0.4794361655237873,"score_spread":0.330243047600126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}