{"id":"W2956128574","doi":"10.1016/j.plasmid.2019.102419","title":"Assembly of large mobilizable genetic cargo by double recombinase operated insertion of DNA (DROID)","year":2019,"lang":"en","type":"article","venue":"Plasmid","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Plasmid; Biology; Recombinase; CRISPR; DNA; Cas9; Trans-activating crRNA; Genetics; Cre recombinase; Computational biology; Insert (composites); Gene; Transgene; Recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009984201,0.0001158769,0.0001732198,0.00003490707,0.0000162059,0.000005657874,0.0001262715,0.0001187461,0.00006411178],"category_scores_gemma":[0.00001422475,0.0001189608,0.00005946215,0.00009741734,0.00001547619,0.000003297258,0.00005900969,0.00004911174,0.00001486013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000781082,"about_ca_system_score_gemma":0.00003957383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006333805,"about_ca_topic_score_gemma":0.00002164418,"domain_scores_codex":[0.9992329,0.00001780614,0.0002356685,0.0002224096,0.00009953637,0.0001916692],"domain_scores_gemma":[0.9995041,0.000007089177,0.00006392837,0.0002940396,0.00008137345,0.00004949024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008668313,0.0001112067,0.004330399,0.00007980586,0.00003229512,3.883765e-7,0.00002714268,0.001992645,0.991666,0.00001427059,0.001566175,0.00009299054],"study_design_scores_gemma":[0.001339217,0.0003261162,0.001587291,0.00001939729,0.0000136724,0.000003460762,0.00004128491,0.001599879,0.9890361,0.000004135486,0.005898442,0.0001310251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969304,0.001034975,0.0008229683,0.00001176684,0.0001702982,0.0002020104,0.00004577751,0.000008905068,0.000772963],"genre_scores_gemma":[0.9984315,0.0001760067,0.0003536989,0.00002437491,0.00001623783,0.00001187584,0.0001557853,0.00002102322,0.0008094771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004332267,"threshold_uncertainty_score":0.4851079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004766488571567525,"score_gpt":0.2601829411904596,"score_spread":0.2554164526188921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}