{"id":"W2956339027","doi":"10.1016/j.ccell.2019.06.003","title":"Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":false,"ca_institutions":"Leukemia & Lymphoma Society of Canada; Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Institut de Valorisation des Données; Université de Montréal; Canada First Research Excellence Fund; Canada Research Chairs; McGill University; Génome Québec; Human Frontier Science Program; Government of Canada; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Genome Canada","keywords":"Myeloid leukemia; Dependency (UML); Cancer research; Leukemia; Oxidative phosphorylation; Cell biology; Biology; Computational biology; Computer science; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436081,0.0003000437,0.0003015145,0.0003197497,0.0003139925,0.0008379135,0.000299229,0.0003085801,0.003606986],"category_scores_gemma":[0.000178888,0.0001743935,0.0001465087,0.0003918523,0.0002186097,0.0003599642,0.0002253843,0.0008154946,0.0005319141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084029,"about_ca_system_score_gemma":0.0003598527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508065,"about_ca_topic_score_gemma":0.004297974,"domain_scores_codex":[0.9998977,0.00001108194,0.000003954358,0.00001802379,0.0000343625,0.00003489404],"domain_scores_gemma":[0.9999603,0.000004478523,0.00001178306,0.000003658989,0.000006723855,0.00001302249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001911118,0.0001514627,0.009021226,0.000361718,0.000117108,0.0003138102,0.0001153921,0.002050979,0.9000629,0.003904301,0.007972669,0.07401731],"study_design_scores_gemma":[0.0003733243,0.002070826,0.1201941,0.0001580532,0.000247945,0.003074684,0.0007601013,0.01048743,0.7438833,0.005482814,0.1132045,0.00006293753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635631,0.02110835,0.001841244,0.002515749,0.000101498,0.0000243764,0.001156083,0.000288505,0.009401082],"genre_scores_gemma":[0.9891036,0.005859749,0.0006387612,0.0004645858,0.00002989095,0.00001511818,0.000720783,0.00002184344,0.003145778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003606986,"threshold_uncertainty_score":0.01206654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398488217436132,"score_gpt":0.2784924626839697,"score_spread":0.2645075805096083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}