{"id":"W2956360859","doi":"10.3389/fgene.2019.00519","title":"Polygenic Risk Score for Alzheimer’s Disease Is Associated With Ch4 Volume in Normal Subjects","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; National Science and Technology Major Project; Centre hospitalier régional universitaire de Lille; H. Lundbeck A/S; Servier; IXICO; Natural Science Foundation of Heilongjiang Province; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; National Natural Science Foundation of China; Eisai; Genentech; Erasmus Medisch Centrum; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; Hjartavernd; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Wellcome Trust; University of Southern California; Université de Lille; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Single-nucleotide polymorphism; Apolipoprotein E; Genome-wide association study; Disease; Internal medicine; Brain size; Medicine; Biology; Genetics; Gene; Genotype; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002455214,0.0001704068,0.0003395008,0.0002941,0.00003626278,0.00001910668,0.0001528209,0.0001397514,0.00004401015],"category_scores_gemma":[0.000105257,0.000149859,0.00007400104,0.0004850514,0.00007383792,0.00005278815,0.00004706143,0.0003016916,0.00001816156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401767,"about_ca_system_score_gemma":0.0003352388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007454748,"about_ca_topic_score_gemma":0.0001182925,"domain_scores_codex":[0.9984544,0.00005362041,0.0002393526,0.0003367114,0.0003599581,0.0005559535],"domain_scores_gemma":[0.999222,0.00003150803,0.00007022998,0.0003605019,0.0001021212,0.0002136626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009394205,0.0001841576,0.979639,0.00004409445,0.0001669947,0.00004837008,0.0002694133,0.00008900642,0.00009099865,9.465529e-7,0.01433985,0.004187777],"study_design_scores_gemma":[0.005059189,0.0008480432,0.9587499,0.000141237,0.0002118343,0.00000212184,0.0001780403,0.03009284,0.0005202708,0.00005326017,0.003916403,0.0002267926],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922786,0.005343175,0.0001879223,0.0002511458,0.0002861242,0.001235342,0.0001226845,0.00001917417,0.0002757982],"genre_scores_gemma":[0.9938279,0.000556168,0.002140912,0.0002631726,0.00006833315,0.00004813479,0.0002369681,0.00004848937,0.002809949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03000383,"threshold_uncertainty_score":0.6111073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761996809408902,"score_gpt":0.2634863632668202,"score_spread":0.2458663951727312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}