{"id":"W2956360859","doi":"10.3389/fgene.2019.00519","title":"Polygenic Risk Score for Alzheimer’s Disease Is Associated With Ch4 Volume in Normal Subjects","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; National Science and Technology Major Project; Centre hospitalier régional universitaire de Lille; H. Lundbeck A/S; Servier; IXICO; Natural Science Foundation of Heilongjiang Province; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; National Natural Science Foundation of China; Eisai; Genentech; Erasmus Medisch Centrum; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; Hjartavernd; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Wellcome Trust; University of Southern California; Université de Lille; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Single-nucleotide polymorphism; Apolipoprotein E; Genome-wide association study; Disease; Internal medicine; Brain size; Medicine; Biology; Genetics; Gene; Genotype; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007728084,0.0006216766,0.0004228254,0.001068116,0.0004166897,0.0006471133,0.000366231,0.000494356,0.003655914],"category_scores_gemma":[0.002610557,0.0002346445,0.001340654,0.0007508168,0.0003751486,0.0002867092,0.0005199636,0.0005803162,0.0003519561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825456,"about_ca_system_score_gemma":0.0002424482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006526323,"about_ca_topic_score_gemma":0.003515306,"domain_scores_codex":[0.9993986,0.0001850004,0.0000549234,0.000200138,0.00009261224,0.00006874106],"domain_scores_gemma":[0.9986414,0.0004799085,0.0003342968,0.0002411471,0.0001349163,0.000168316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001176022,0.0001006407,0.9836059,0.0000364639,0.001408949,0.0005759159,0.000137185,0.0006668624,0.003935819,0.0003025151,0.0004830712,0.007570614],"study_design_scores_gemma":[0.00002198042,0.0001621048,0.995558,0.000005351032,0.000269304,0.00056698,0.00005116742,0.00249932,0.0002323222,0.0003867871,0.0002373266,0.000009346199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974186,0.0003020979,0.001022806,0.00007164929,0.0000178762,0.00001007216,0.0004119308,0.00004572537,0.0006991773],"genre_scores_gemma":[0.9988079,0.00004888274,0.0003083482,0.00001390148,0.00001331899,0.000009098928,0.0004248979,0.000006880634,0.00036672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006526323,"threshold_uncertainty_score":0.01297665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01761996809408902,"score_gpt":0.2634863632668202,"score_spread":0.2458663951727312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}