{"id":"W2956512450","doi":"10.3390/cancers11071002","title":"Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Vetenskapsrådet","keywords":"Sunitinib; Metastasis; Angiogenesis; Cancer research; Triple-negative breast cancer; Medicine; Tumor hypoxia; Breast cancer; Metastatic breast cancer; Primary tumor; Hypoxia (environmental); Lung cancer; Cancer; Internal medicine; Radiation therapy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105629,0.0002399425,0.0002897904,0.0001354078,0.00008130351,0.000222353,0.0001701117,0.0001742251,0.0008042951],"category_scores_gemma":[0.00008716497,0.00009458393,0.0001259778,0.00009973145,0.0001540287,0.0001399224,0.0001461786,0.0004301093,0.0001045242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003342636,"about_ca_system_score_gemma":0.0004362128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455105,"about_ca_topic_score_gemma":0.002981136,"domain_scores_codex":[0.9998969,0.00001440611,0.000007294845,0.00001655312,0.00003080055,0.00003411018],"domain_scores_gemma":[0.9999458,0.000007258684,0.00001618085,0.000004315776,0.000005883522,0.00002055154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001582928,0.00007376005,0.0001364348,0.00003061264,0.000006902552,0.0000171732,0.000006991614,0.0001578441,0.9974522,0.00009820394,0.00008471654,0.001776887],"study_design_scores_gemma":[0.00004888148,0.001046583,0.003211347,0.000003759706,0.00002192071,0.0001303445,0.00001565144,0.001638842,0.9915835,0.00003461677,0.002260558,0.000003926402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960009,0.0007470569,0.001379199,0.0001203484,0.00002358894,0.00003442309,0.0001592127,0.00007599463,0.001459059],"genre_scores_gemma":[0.997153,0.0003918499,0.0007098784,0.00003610491,0.000005470404,0.00002266859,0.0001866053,0.00001264856,0.001481668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455105,"threshold_uncertainty_score":0.002893329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004442968426183,"score_gpt":0.2592070315480233,"score_spread":0.2491626018637615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}