{"id":"W2956512450","doi":"10.3390/cancers11071002","title":"Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Vetenskapsrådet","keywords":"Sunitinib; Metastasis; Angiogenesis; Cancer research; Triple-negative breast cancer; Medicine; Tumor hypoxia; Breast cancer; Metastatic breast cancer; Primary tumor; Hypoxia (environmental); Lung cancer; Cancer; Internal medicine; Radiation therapy; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328356,0.0001326565,0.0001823021,0.00005811563,0.00006783466,0.00002095282,0.00005728734,0.00009225428,0.0001347956],"category_scores_gemma":[0.00001995193,0.0001299062,0.00008320453,0.0001734965,0.00006709303,0.00001539606,0.00004357701,0.00005503002,7.893924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001076185,"about_ca_system_score_gemma":0.000270664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217864,"about_ca_topic_score_gemma":0.0001156225,"domain_scores_codex":[0.9991477,0.00006414211,0.0001895722,0.000311373,0.0001064187,0.000180795],"domain_scores_gemma":[0.9995091,0.000007441958,0.0001600412,0.0001417841,0.0001132541,0.00006835638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212209,0.000008658511,0.002633689,0.00005690118,0.0001266328,5.423224e-7,0.0001231214,0.0002009623,0.9924481,0.000008033869,0.001492619,0.002779538],"study_design_scores_gemma":[0.000701215,0.0000607519,0.00241006,0.00005877225,0.0000839577,0.00000453603,0.0007289347,0.0003366804,0.9946629,0.000004381591,0.0007687717,0.000179065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959936,0.002660632,0.00004809905,0.0001211621,0.0005780266,0.0001731289,0.0001005778,0.0000106538,0.0003141208],"genre_scores_gemma":[0.9988514,0.0004151621,0.00009896429,0.0001332845,0.000211843,0.00002595747,0.00006560896,0.00001854903,0.0001792867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002857745,"threshold_uncertainty_score":0.5297421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004442968426183,"score_gpt":0.2592070315480233,"score_spread":0.2491626018637615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}