{"id":"W2956532717","doi":"10.1161/circulationaha.119.042007","title":"Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups","year":2019,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of British Columbia","funders":"Merck Sharp and Dohme; University of California, San Francisco; Astellas Pharma; Eisai; NxStage; Medical Research Council; Verily Life Sciences; National Health and Medical Research Council; AstraZeneca; Amarin Corporation; National Institutes of Health; Regeneron Pharmaceuticals; Pfizer; Innovent Biologics; Janssen Pharmaceuticals; Ablynx; University of Washington; Ironwood Pharmaceuticals, Incorporated; Relypsa; University of Chicago; Alnylam Pharmaceuticals; Novo Nordisk; MyoKardia; Daiichi Sankyo Europe; Servier; Gilead Sciences; George Institute for Global Health; Kidney Foundation of Canada; Kowa Company; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; GlaxoSmithKline; Amgen; Celgene; Eli Lilly and Company; Akebia Therapeutics; Bristol-Myers Squibb","keywords":"Medicine; Canagliflozin; Diabetes mellitus; Kidney disease; Internal medicine; Hazard ratio; Myocardial infarction; Stroke (engine); Type 2 diabetes; Heart failure; Type 2 Diabetes Mellitus; Endocrinology; Confidence interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003321957,0.0001485515,0.0004318177,0.0001847931,0.00002711966,0.00002965713,0.00001786237,0.00005820852,0.00001094128],"category_scores_gemma":[0.00002789003,0.0001400314,0.00008538285,0.0001186231,0.00004327776,0.0002052787,0.00005525743,0.0000821186,0.000001745369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347034,"about_ca_system_score_gemma":0.0000678192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001095036,"about_ca_topic_score_gemma":0.00003732295,"domain_scores_codex":[0.999005,0.00006945648,0.0001778592,0.0003801375,0.0001844776,0.000183132],"domain_scores_gemma":[0.9995316,0.00002228909,0.00002907614,0.0002499921,0.00001814531,0.0001488847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002653817,0.00004127582,0.9377432,0.0008494699,0.0006599669,0.00001984949,0.00009287379,0.0001138237,0.0001832477,0.00007484741,0.000009389757,0.06018549],"study_design_scores_gemma":[0.003711503,0.00007754943,0.9923407,0.0002455901,0.0006271456,0.000001708146,0.00002042277,0.001423974,0.00001849369,0.0002602072,0.001134325,0.0001384217],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9246119,0.07406812,0.00001384642,0.00009760482,0.00006434221,0.0009021832,0.000004444021,0.00001643489,0.0002211458],"genre_scores_gemma":[0.9969753,0.002625776,0.00004860256,0.0000777786,0.00003027035,0.0000323564,0.000141176,0.00001577534,0.0000529394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07236345,"threshold_uncertainty_score":0.5710313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007023360233193048,"score_gpt":0.2075296266487411,"score_spread":0.200506266415548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}