{"id":"W2956561172","doi":"10.1111/xen.12535","title":"Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome","year":2019,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Seventh Framework Programme; Ministry of Science, Technology and Space","keywords":"Xenotransplantation; Biology; Antibody; Chemokine; Immunology; Transcriptome; Molecular biology; Gene; Immune system; Transplantation; Gene expression; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023027,0.0001100919,0.0002310126,0.0002187439,0.0002078036,0.0003658611,0.00006775597,0.000188379,0.001251347],"category_scores_gemma":[0.0001667815,0.00009529262,0.0002270592,0.0003575433,0.00009618547,0.0001267821,0.0001561516,0.000310153,0.0003012352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361794,"about_ca_system_score_gemma":0.0001891205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008035084,"about_ca_topic_score_gemma":0.0009969871,"domain_scores_codex":[0.9998446,0.00001385236,0.00001009041,0.0000623069,0.00002845393,0.00004064689],"domain_scores_gemma":[0.9999371,0.00001508205,0.00001329753,0.000005364814,0.00002003226,0.000009127528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004652553,0.00004382776,0.01631103,0.0001986538,0.00004948229,0.0002670852,0.0002663486,0.0002217575,0.9691582,0.0001303369,0.0004994635,0.01238852],"study_design_scores_gemma":[0.00003630888,0.0007609878,0.591946,0.0001151395,0.0002696225,0.00146641,0.001298847,0.002826642,0.3794033,0.0004370848,0.02139208,0.0000476534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886107,0.003055228,0.001594974,0.00008402495,0.00003368695,0.00002594409,0.004685849,0.00003576305,0.001873799],"genre_scores_gemma":[0.98175,0.002208226,0.002252666,0.0003230557,0.00002566314,0.0001028436,0.008255136,0.00002549146,0.005057074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251347,"threshold_uncertainty_score":0.004186153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774525077520429,"score_gpt":0.2738618004556777,"score_spread":0.2561165496804734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}