{"id":"W2956561172","doi":"10.1111/xen.12535","title":"Elicited and pre‐existing anti‐Neu5Gc antibodies differentially affect human endothelial cells transcriptome","year":2019,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Seventh Framework Programme; Ministry of Science, Technology and Space","keywords":"Xenotransplantation; Biology; Antibody; Chemokine; Immunology; Transcriptome; Molecular biology; Gene; Immune system; Transplantation; Gene expression; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338644,0.0002256676,0.0003169386,0.0001342492,0.0002102578,0.00004241687,0.0001389148,0.0001240359,0.0005773637],"category_scores_gemma":[0.000005333983,0.0002126765,0.00008382137,0.00006957489,0.00008601311,0.0001407703,0.00001453276,0.000140886,0.0001841261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001731568,"about_ca_system_score_gemma":0.00001454689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001571527,"about_ca_topic_score_gemma":0.00005560926,"domain_scores_codex":[0.9986851,0.0002331155,0.0003377635,0.0003610975,0.00006718663,0.0003157741],"domain_scores_gemma":[0.9994721,0.000164958,0.0001173088,0.0001834451,0.00003776029,0.00002445727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149219,0.00006634414,0.0491051,0.0004117998,0.0001244204,0.000003915992,0.001403181,0.00001248266,0.9478385,0.0005718081,0.00008593206,0.0002272407],"study_design_scores_gemma":[0.003396682,0.0002557581,0.4061076,0.0003148035,0.0002484399,0.00004075087,0.00014795,0.00002571687,0.5883414,0.00008959854,0.0006627965,0.0003684952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960371,0.0003568331,0.0005566862,0.00002990215,0.0007034788,0.0007339398,0.00052782,0.0001580077,0.0008962065],"genre_scores_gemma":[0.9979693,0.0000855046,0.00002898963,0.00005012829,0.00004037066,0.00002014492,0.0008354388,0.00002494102,0.000945195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3594971,"threshold_uncertainty_score":0.8672697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01774525077520429,"score_gpt":0.2738618004556777,"score_spread":0.2561165496804734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}