{"id":"W2956644939","doi":"10.1016/j.ccell.2019.06.002","title":"A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor","year":2019,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; McMaster University; Hospital for Sick Children; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Ottawa; McGill University; University of Calgary; Children's Hospital of Eastern Ontario; Alberta Children's Hospital; Ontario Institute for Cancer Research; University of Toronto; SickKids Foundation","funders":"Canadian Institutes of Health Research","keywords":"Enhancer; Vulnerability (computing); Biology; Cancer research; Gene; Genetics; Computer science; Computer security; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009450379,0.0002654365,0.0001805943,0.0001974147,0.0001777853,0.0003097437,0.0002322663,0.0003061567,0.003219854],"category_scores_gemma":[0.0000970507,0.00009437366,0.0001856738,0.00008483417,0.0002642875,0.0001980403,0.0002648285,0.0006679969,0.0004937907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990065,"about_ca_system_score_gemma":0.0001824864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004744656,"about_ca_topic_score_gemma":0.0007736325,"domain_scores_codex":[0.9998683,0.00001073376,0.000005864279,0.00004063638,0.00003552568,0.00003894209],"domain_scores_gemma":[0.9999369,0.000009361819,0.00001460111,0.0000110818,0.000004993507,0.00002303549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008508784,0.00001931776,0.0001325272,0.00000779202,0.000003623239,0.00008820296,0.000004920734,0.00008025603,0.9975033,0.0007173592,0.00005416735,0.001303524],"study_design_scores_gemma":[0.00001911142,0.0002448465,0.002501271,0.000002777143,0.00001261339,0.0008861146,0.00002472133,0.00207973,0.989546,0.0003876572,0.004289537,0.000005582566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989029,0.0005428434,0.006105838,0.000190391,0.00004361742,0.00002861262,0.000335807,0.000241696,0.003482119],"genre_scores_gemma":[0.9958959,0.0001117798,0.001437986,0.0000516131,0.0000038608,0.00001474479,0.0001591756,0.00003989374,0.002284957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003219854,"threshold_uncertainty_score":0.01077145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176166883474966,"score_gpt":0.2601869070302388,"score_spread":0.2484252381954892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}