{"id":"W2956843874","doi":"10.1021/jacs.9b03307","title":"An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced <i>in Situ</i> by a Partner Oxidase.","year":2019,"lang":"en","type":"paratext","venue":"PubMed","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Alfred P. Sloan Foundation","keywords":"Chemistry; Amino acid; Oxidase test; Stereochemistry; Mutagenesis; Imine; Reductase; Enzyme; Cofactor; Biochemistry; Catalysis; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0008865089,0.0006547915,0.0008398569,0.0005996122,0.00009647792,0.0003532375,0.0008629695,0.0006515327,0.001305578],"category_scores_gemma":[0.000151795,0.0005601951,0.0001611827,0.0007529599,0.0001231265,0.0006669584,0.0001640962,0.0006625041,0.004929637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788983,"about_ca_system_score_gemma":0.0001041145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001423455,"about_ca_topic_score_gemma":0.00004391774,"domain_scores_codex":[0.9956783,0.0003806227,0.0006061324,0.001530933,0.0006173932,0.001186642],"domain_scores_gemma":[0.9977488,0.00008127475,0.0004413361,0.001316946,0.00008609919,0.0003255533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798172,0.0001637712,0.0002021841,0.0001715588,0.00002255373,0.000008832153,0.0001859722,0.00001326534,0.3007039,0.00000718716,0.6729149,0.02542618],"study_design_scores_gemma":[0.0009551722,0.000111805,0.006485903,0.00005508156,0.00007142322,0.00002444689,0.00008224368,0.000002914875,0.790332,0.00004168602,0.2009299,0.0009074558],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.87744,0.00233529,0.00008066645,0.0003580309,0.01979936,0.00365137,0.0006667254,0.000186024,0.09548249],"genre_scores_gemma":[0.9323997,0.0001469814,0.00006300494,0.0005724428,0.001145181,0.001932212,0.001158942,0.0001040855,0.06247746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4896281,"threshold_uncertainty_score":0.9996849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306264989628104,"score_gpt":0.2555521157491908,"score_spread":0.2324894658529098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}