{"id":"W2956843874","doi":"10.1021/jacs.9b03307","title":"An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced <i>in Situ</i> by a Partner Oxidase.","year":2019,"lang":"en","type":"paratext","venue":"PubMed","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Alfred P. Sloan Foundation","keywords":"Chemistry; Amino acid; Oxidase test; Stereochemistry; Mutagenesis; Imine; Reductase; Enzyme; Cofactor; Biochemistry; Catalysis; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220143,0.0003012576,0.00009371863,0.0001306559,0.0001298257,0.0002248964,0.0003647159,0.0002962527,0.002325096],"category_scores_gemma":[0.0001166059,0.0001255428,0.000128824,0.0001955559,0.0001081081,0.0003032115,0.0001448466,0.0002316102,0.001054079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003986672,"about_ca_system_score_gemma":0.0001427323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008734234,"about_ca_topic_score_gemma":0.001281365,"domain_scores_codex":[0.9999398,0.000007081986,0.000002900375,0.00001638953,0.00002392839,0.000009882763],"domain_scores_gemma":[0.9999788,0.000002722808,0.000005775239,0.000002819411,0.000003195689,0.000006790217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007504901,0.00002851143,0.0004819519,0.0001041702,0.00001117295,0.0002353663,0.00002671319,0.0002884571,0.9876323,0.001313201,0.0007540974,0.009049091],"study_design_scores_gemma":[0.00001272015,0.0001608614,0.001811213,0.00000637989,0.00001608555,0.000552103,0.00004582722,0.003158421,0.9728252,0.0001581817,0.02124566,0.000007365638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9461823,0.003325136,0.02434496,0.0003990437,0.000145276,0.00006165021,0.001165362,0.000618625,0.02375762],"genre_scores_gemma":[0.9693422,0.001227477,0.01317884,0.00005032906,0.00001044993,0.00001503807,0.002026656,0.00004675048,0.01410223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002325096,"threshold_uncertainty_score":0.007778168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306264989628104,"score_gpt":0.2555521157491908,"score_spread":0.2324894658529098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}