{"id":"W2956909849","doi":"10.1200/jco.2019.37.15_suppl.7056","title":"A phase II study of cpi-0610, a bromodomain and extraterminal protein inhibitor (BETi) alone or with ruxolitinib (RUX), in patients with myelofibrosis (MF).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myelofibrosis; Internal medicine; Ruxolitinib; Anemia; Gastroenterology; Oncology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001548541,0.001702214,0.002067974,0.000570902,0.0003609876,0.001084529,0.001128035,0.001625009,0.007435527],"category_scores_gemma":[0.0009516058,0.000768829,0.001578508,0.0004533117,0.001027287,0.00126934,0.0004844562,0.003730669,0.001571646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008544275,"about_ca_system_score_gemma":0.001476584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007226725,"about_ca_topic_score_gemma":0.00210357,"domain_scores_codex":[0.9995645,0.0001878759,0.00001843281,0.00008527462,0.00003780122,0.0001061694],"domain_scores_gemma":[0.9993704,0.0001046524,0.0001092591,0.00005742278,0.0000351077,0.0003231743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8266365,0.07184336,0.002491858,0.0007834639,0.0008587968,0.000202276,0.000246483,0.001796179,0.02279858,0.0004001889,0.003127064,0.06881527],"study_design_scores_gemma":[0.621967,0.3707741,0.003357931,0.00003216135,0.0002255116,0.0001893228,0.00004094622,0.0006629224,0.001147104,0.0001869787,0.001391035,0.00002501109],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872463,0.002519079,0.0006931231,0.0007184392,0.0002549379,0.00396256,0.001212358,0.0001396743,0.003253506],"genre_scores_gemma":[0.9821294,0.002509889,0.002467165,0.001296903,0.0002671629,0.004130256,0.002334168,0.00003307179,0.004831994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007435527,"threshold_uncertainty_score":0.02487433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0526204380176043,"score_gpt":0.4045944892902081,"score_spread":0.3519740512726038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}