{"id":"W2957045816","doi":"10.1038/s41467-019-11005-2","title":"Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University College London; Wellcome Trust; Medical Research Council; Wellcome; National Institute for Health and Care Research; Department of Health and Social Care; Government of the United Kingdom; University College London Hospitals NHS Foundation Trust; Bill and Melinda Gates Foundation","keywords":"Colonisation; Innate immune system; Streptococcus pneumoniae; Microbiology; Immunity; Immunology; Biology; Immune system; Colonization; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0003206118,0.0001937878,0.0002268811,0.00008178757,0.001623077,0.00004857932,0.000649689,0.0003950937,0.0001119775],"category_scores_gemma":[0.00009201927,0.0001430657,0.0001304023,0.0003739343,0.0002542449,0.0001325714,0.0005211238,0.001887784,0.0002158218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801093,"about_ca_system_score_gemma":0.0001132615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000823399,"about_ca_topic_score_gemma":0.0005476585,"domain_scores_codex":[0.9986124,0.0003422525,0.0003230572,0.0002331091,0.0002446951,0.0002444859],"domain_scores_gemma":[0.9970809,0.0002582401,0.0002011327,0.002188374,0.0001799276,0.00009145938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000008653958,0.0001979542,0.1102343,0.00001932846,0.00005190039,7.080689e-7,0.0003697169,0.00001381375,0.8876499,0.0001779723,0.001209829,0.00006589839],"study_design_scores_gemma":[0.001440936,0.0001639405,0.7343125,0.00009690398,0.0001233806,0.00004442514,0.0004607702,0.000053773,0.1520478,0.00004595873,0.1109333,0.0002762505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826645,0.00128953,6.249559e-7,0.01216167,0.000234345,0.00093934,0.000100042,0.0001367735,0.002473231],"genre_scores_gemma":[0.9966513,0.0003313824,0.00002561081,0.000613128,0.00005021221,0.0000512896,0.0003634021,0.0000304357,0.001883226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7356021,"threshold_uncertainty_score":0.9996766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855719082215918,"score_gpt":0.3041152719492739,"score_spread":0.2855580811271147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}