{"id":"W2957045816","doi":"10.1038/s41467-019-11005-2","title":"Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University College London; Wellcome Trust; Medical Research Council; Wellcome; National Institute for Health and Care Research; Department of Health and Social Care; Government of the United Kingdom; University College London Hospitals NHS Foundation Trust; Bill and Melinda Gates Foundation","keywords":"Colonisation; Innate immune system; Streptococcus pneumoniae; Microbiology; Immunity; Immunology; Biology; Immune system; Colonization; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002160081,0.000186246,0.0002442296,0.0001492666,0.0001198928,0.0003734183,0.00007769606,0.0003202852,0.001112363],"category_scores_gemma":[0.0001603037,0.0001518611,0.0002290328,0.0001284184,0.00024856,0.0001600411,0.0002791673,0.0005419925,0.0002547306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842863,"about_ca_system_score_gemma":0.0002294861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004852492,"about_ca_topic_score_gemma":0.0006948092,"domain_scores_codex":[0.9997053,0.000087606,0.00001674164,0.00004060075,0.00006716658,0.00008266438],"domain_scores_gemma":[0.9998872,0.00002942369,0.00002128968,0.00002192877,0.00001362007,0.00002651393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003200564,0.00003926309,0.0006514486,0.0000291077,0.000002663092,0.00006551638,0.00003029046,0.00005007874,0.9979678,0.00002880419,0.00001470412,0.0008003592],"study_design_scores_gemma":[0.00002701669,0.002935862,0.0619049,0.00001817652,0.00001844759,0.0007426827,0.0002876297,0.0009671165,0.9315575,0.00009965797,0.001432994,0.000008097467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983492,0.0005226587,0.0005188287,0.00003391267,0.000007446145,0.00001714619,0.0001050172,0.00001335423,0.0004323183],"genre_scores_gemma":[0.9981634,0.0002977621,0.0005901197,0.00003646085,0.000005079524,0.00002431294,0.0002001904,0.000003339583,0.0006793377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112363,"threshold_uncertainty_score":0.003721237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855719082215918,"score_gpt":0.3041152719492739,"score_spread":0.2855580811271147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}