{"id":"W2957253824","doi":"10.1016/j.clcc.2019.07.007","title":"Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab","year":2019,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Society for Medical Oncology; Manitoba Beekeepers' Association; Gilead Sciences; Novartis; British Microcirculation Society; Amgen; Pfizer; F. Hoffmann-La Roche; Hellenic Cooperative Oncology Group; Roche; Meso Scale Diagnostics; Sanofi; Merck","keywords":"Bevacizumab; Medicine; Irinotecan; Colorectal cancer; Oncology; Internal medicine; Retrospective cohort study; Prospective cohort study; Chemotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004184296,0.0003907612,0.0007379377,0.0001179239,0.0000680489,0.00002766015,0.0001784057,0.0003341156,0.0000771944],"category_scores_gemma":[0.00005030956,0.0003389643,0.0001358476,0.0004707694,0.0002466128,0.00001802993,0.0001024049,0.0002482035,0.000003098123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141896,"about_ca_system_score_gemma":0.0003239877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001752405,"about_ca_topic_score_gemma":0.008934888,"domain_scores_codex":[0.9972654,0.0001876115,0.0005361736,0.001267234,0.0002695417,0.0004740187],"domain_scores_gemma":[0.9991078,0.00006386009,0.0002239325,0.0002539438,0.0002013792,0.0001491209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006586363,0.0008534422,0.9871105,0.00001940395,0.0003377677,0.000008941285,0.00009223287,0.0000369365,0.003188326,0.000002085608,0.00003538927,0.001728633],"study_design_scores_gemma":[0.01070795,0.006319394,0.9762087,0.0000695118,0.00009365829,0.000002056065,0.00005715264,0.0001831742,0.005852102,0.000004762112,0.00004506431,0.0004564182],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950597,0.001736735,0.00000260861,0.00005221471,0.00016646,0.002690724,0.0001140062,0.00001872382,0.0001588115],"genre_scores_gemma":[0.9978459,0.001031739,0.00003116379,0.0001906415,0.0001320267,0.0006196637,0.00004018189,0.00006587275,0.000042752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01090172,"threshold_uncertainty_score":0.9999062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008801961380234487,"score_gpt":0.2903455097289728,"score_spread":0.2815435483487383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}