{"id":"W2957253824","doi":"10.1016/j.clcc.2019.07.007","title":"Angiogenic and Antiangiogenic VEGFA Splice Variants in Colorectal Cancer: Prospective Retrospective Cohort Study in Patients Treated With Irinotecan-Based Chemotherapy and Bevacizumab","year":2019,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Society for Medical Oncology; Manitoba Beekeepers' Association; Gilead Sciences; Novartis; British Microcirculation Society; Amgen; Pfizer; F. Hoffmann-La Roche; Hellenic Cooperative Oncology Group; Roche; Meso Scale Diagnostics; Sanofi; Merck","keywords":"Bevacizumab; Medicine; Irinotecan; Colorectal cancer; Oncology; Internal medicine; Retrospective cohort study; Prospective cohort study; Chemotherapy; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003183026,0.0002972318,0.0005427338,0.000571794,0.0005315933,0.0008055795,0.0003097951,0.0005224897,0.001327475],"category_scores_gemma":[0.001116663,0.0004776648,0.0006385205,0.001240091,0.0003725837,0.0004366063,0.0002922818,0.0007219167,0.0002433839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803168,"about_ca_system_score_gemma":0.0003634172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003645689,"about_ca_topic_score_gemma":0.003595216,"domain_scores_codex":[0.9995541,0.00006680012,0.00005388847,0.0001763353,0.00006729908,0.00008159731],"domain_scores_gemma":[0.9989863,0.0001517003,0.000484693,0.0000999882,0.00008623025,0.0001911103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007047171,0.00004526223,0.9974805,0.000006750534,0.00009209626,0.0001823859,0.00004457737,0.00003251195,0.0007494498,0.0000212834,0.00004044947,0.0006000464],"study_design_scores_gemma":[0.00002760976,0.0002823241,0.9982355,0.000003076737,0.00009345813,0.0007244034,0.0001586691,0.0001264115,0.0001297488,0.00002084655,0.000191602,0.0000063468],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993877,0.0001891959,0.00004795718,0.00001115209,0.000004824712,0.000004940234,0.000185467,0.000001502437,0.0001672761],"genre_scores_gemma":[0.9994612,0.00007614673,0.0000385342,0.00001922796,0.000007672958,0.000005963852,0.0002598125,0.000002626585,0.0001287688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645689,"threshold_uncertainty_score":0.007248938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008801961380234487,"score_gpt":0.2903455097289728,"score_spread":0.2815435483487383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}