{"id":"W2957262648","doi":"10.1093/annonc/mdz154.019","title":"Copy number variation in longitudinal liver metastases biopsies in colorectal cancer identifies biomarker candidates of resistance to standard chemotherapy","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Moncton Hospital; Mount Sinai Hospital; Jewish General Hospital; Sunnybrook Health Science Centre; Dr. Georges-L.-Dumont University Hospital Centre; Hôpital Maisonneuve-Rosemont; St Mary's Hospital Centre; McGill University Health Centre; McGill University; Hôpital du Sacré-Cœur de Montréal; Cégep de Lévis; Quebec - Clinical Research Organization in Cancer; Centre de Santé et de Services Sociaux de Chicoutimi","funders":"","keywords":"Medicine; KRAS; Context (archaeology); Colorectal cancer; Oncology; Metastasis; Cancer; Internal medicine; Copy-number variation; Chemotherapy regimen; Biopsy; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003613134,0.0001751644,0.0001975057,0.0007616085,0.0001772149,0.0005480149,0.0002210137,0.0003676556,0.001266561],"category_scores_gemma":[0.001975696,0.0002099768,0.0001655487,0.0004282532,0.0001887435,0.0002222807,0.0002141506,0.0003007026,0.0002483217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174616,"about_ca_system_score_gemma":0.0001377108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002231419,"about_ca_topic_score_gemma":0.004176945,"domain_scores_codex":[0.9997433,0.00005290181,0.00001762132,0.00008228024,0.00006667109,0.00003725215],"domain_scores_gemma":[0.9991399,0.000273896,0.0003340397,0.00006687263,0.0001168389,0.00006832254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001033653,0.00003513448,0.9002897,0.00002744456,0.0001412122,0.0003335005,0.000121222,0.0006292273,0.08486549,0.0001093222,0.0001860073,0.01222808],"study_design_scores_gemma":[0.000006778364,0.0001364333,0.9888537,0.000004974077,0.00004586932,0.0009552646,0.00007640379,0.001588696,0.007940056,0.00008729881,0.000298245,0.00000641311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986242,0.0003213101,0.0003774285,0.00004701774,0.000004440875,0.000003496657,0.0002919608,0.00001779141,0.0003123209],"genre_scores_gemma":[0.9991047,0.00006805929,0.0002780806,0.00002130928,0.000005026796,0.00000469259,0.0002005225,0.000006155489,0.0003115727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002231419,"threshold_uncertainty_score":0.004436851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0244199750456976,"score_gpt":0.3438235205356684,"score_spread":0.3194035454899709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}