{"id":"W2957683864","doi":"10.1002/jnr.24495","title":"Dysfunctional striatal dopamine signaling in Huntington's disease","year":2019,"lang":"en","type":"review","venue":"Journal of Neuroscience Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research; Huntington Society of Canada","keywords":"Dopamine; Striatum; Neuroscience; Huntingtin; Dopaminergic; Substantia nigra; Huntington's disease; Dopamine receptor; Basal ganglia; Huntingtin Protein; Genetic model; Biology; Psychology; Medicine; Disease; Internal medicine; Central nervous system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374738,0.0006882892,0.0009468745,0.002176169,0.0002546085,0.000701631,0.0006290337,0.0009326973,0.002756914],"category_scores_gemma":[0.0002983758,0.000236352,0.0002594992,0.001878171,0.0003461579,0.0008828911,0.0005812263,0.0013002,0.00251275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005411173,"about_ca_system_score_gemma":0.000652862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107663,"about_ca_topic_score_gemma":0.002649675,"domain_scores_codex":[0.9999225,0.00001109607,0.0000129752,0.00001406594,0.00003160241,0.000007688985],"domain_scores_gemma":[0.9998975,0.00003434349,0.00001633636,0.000002876217,0.00003493462,0.00001407544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00007651086,0.00005739155,0.0001670118,0.01039448,0.00004767251,0.0002969479,0.00006033264,0.000264016,0.001733556,0.002943492,0.03991115,0.9440474],"study_design_scores_gemma":[0.00001743334,0.00008992595,0.001210324,0.003048718,0.00006457441,0.002083572,0.00005191062,0.00007579511,0.000300606,0.002046463,0.9909939,0.00001675237],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009385504,0.9985038,0.00005534259,0.0001766095,0.0001667271,0.000002544674,0.00001110162,0.000004951214,0.0009851184],"genre_scores_gemma":[0.0004798755,0.998535,0.00008191109,0.0001317452,0.0001295952,0.000003239912,0.00001938798,8.938106e-7,0.0006183914],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002756914,"threshold_uncertainty_score":0.009222806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3101215210248098,"score_gpt":0.457033677379011,"score_spread":0.1469121563542012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}