{"id":"W2957711757","doi":"10.1016/j.xcrm.2020.100096","title":"Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection","year":2019,"lang":"en","type":"preprint","venue":"Cell Reports Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute on Aging; Janssen Biotech; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Cancer Institute; National Institutes of Health; James B. Pendleton Charitable Trust; Merck; Bill and Melinda Gates Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Janssen Pharmaceuticals; Gilead Sciences; National Institute of Allergy and Infectious Diseases","keywords":"Duodenum; Gastrointestinal tract; Medicine; Interferon; Biopsy; Rectum; Immune system; Intestinal mucosa; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007801768,0.000311649,0.0006202196,0.0002410607,0.00005308068,0.00001121593,0.0002678367,0.0003664521,0.0001006269],"category_scores_gemma":[0.00005270823,0.000133057,0.00006971552,0.000265507,0.0003703105,0.00003326302,0.0001036435,0.001133564,0.00002810369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001588292,"about_ca_system_score_gemma":0.0003163686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006147052,"about_ca_topic_score_gemma":0.0007445753,"domain_scores_codex":[0.998001,0.0005344096,0.000543703,0.0004357761,0.0001702426,0.0003149173],"domain_scores_gemma":[0.9982328,0.0003411966,0.0004577062,0.0008729277,0.00007737608,0.0000179851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002922959,0.003712548,0.7552909,0.0006813571,0.0008335923,0.004623302,0.1042989,0.0002238038,0.1068604,0.00005370313,0.007832678,0.01266583],"study_design_scores_gemma":[0.03740356,0.07345501,0.7104209,0.008442053,0.001304308,0.004224828,0.03963048,0.0000454172,0.06979068,0.0006945065,0.05255193,0.002036341],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882598,0.004176096,0.000008008303,0.0007236524,0.0005196352,0.001405922,0.00001137377,0.00001380605,0.004881704],"genre_scores_gemma":[0.9970022,0.0007206589,0.000003618819,0.00005942635,0.00004478597,0.00009275351,0.0007802795,0.00001414161,0.001282069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06974246,"threshold_uncertainty_score":0.9292544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971984486399824,"score_gpt":0.2800362952733871,"score_spread":0.2603164504093888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}