{"id":"W2957757085","doi":"10.1016/j.vaccine.2019.07.044","title":"Therapeutic vaccines for amyotrophic lateral sclerosis directed against disease specific epitopes of superoxide dismutase 1","year":2019,"lang":"en","type":"article","venue":"Vaccine","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"Weston Brain Institute","keywords":"SOD1; Epitope; Amyotrophic lateral sclerosis; Immunogenicity; Immunology; Superoxide dismutase; Disease; Immune system; Biology; Medicine; Antibody; Oxidative stress; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002040918,0.0004923309,0.0003023582,0.0002774019,0.0001191734,0.0001954893,0.0001907973,0.0005180412,0.001512521],"category_scores_gemma":[0.0001119598,0.0001358262,0.0001753332,0.000110993,0.0002721222,0.0002665648,0.0001912578,0.0009030381,0.0002733962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060899,"about_ca_system_score_gemma":0.0001826694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840955,"about_ca_topic_score_gemma":0.0002980761,"domain_scores_codex":[0.999885,0.00002531941,0.000009609595,0.00002706741,0.00002615412,0.00002690132],"domain_scores_gemma":[0.9999518,0.000007617797,0.00001656704,0.000005153477,0.000004251929,0.00001451179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003820612,0.000228004,0.00009250948,0.00006546904,0.00001274218,0.00003385785,0.00001858214,0.0002455428,0.995599,0.0003683999,0.0001539739,0.00279988],"study_design_scores_gemma":[0.0003146374,0.00504584,0.002039718,0.00003050621,0.00004381163,0.0005180744,0.00002972767,0.002648619,0.9800814,0.0003034588,0.008933329,0.00001086858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884934,0.001370655,0.00693874,0.0003578615,0.0001736116,0.0001394047,0.0004540954,0.0001505534,0.001921799],"genre_scores_gemma":[0.9910279,0.0008591518,0.004446644,0.0001242446,0.00002606551,0.0001362953,0.000593152,0.00002248215,0.00276402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512521,"threshold_uncertainty_score":0.005059898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03700665488101867,"score_gpt":0.2742052695848773,"score_spread":0.2371986147038586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}