{"id":"W2957905619","doi":"10.15252/embj.2018101284","title":"Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing","year":2019,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Genève; Institut National Du Cancer; Ligue Contre le Cancer; Ministerio de Ciencia, Tecnología e Innovación Productiva; Consejo Nacional de Investigaciones Científicas y Técnicas; Associazione Italiana per la Ricerca sul Cancro; Agencia Nacional de Promoción Científica y Tecnológica; Agence Nationale de la Recherche; York University; University of Sussex; Johns Hopkins University; European Commission; Universidad Nacional de Córdoba","keywords":"Humanities; Biology; Art","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000819042,0.0001209325,0.000152397,0.00003016337,0.00009546176,0.00004010912,0.0004462956,0.00008085171,0.000156194],"category_scores_gemma":[0.00004074924,0.00008795706,0.0001086848,0.0000502632,0.00004702432,0.000008885063,0.0001093924,0.0001868025,0.00001917626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001951534,"about_ca_system_score_gemma":0.00007597181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154119,"about_ca_topic_score_gemma":0.00000380555,"domain_scores_codex":[0.9989999,0.0001252756,0.0002125767,0.0002221454,0.000242854,0.000197237],"domain_scores_gemma":[0.9989533,0.00002074848,0.0002539146,0.0005858333,0.00008643768,0.00009970963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372673,0.0000295389,0.0270578,0.00002467229,0.00006161575,0.000004570481,0.000164116,0.0002903259,0.9713793,0.00009016952,0.0002055968,0.000555052],"study_design_scores_gemma":[0.0007247789,0.0001375391,0.002605813,0.0000238481,0.00002580363,0.0001190091,0.0002847456,0.0001930303,0.9932747,0.0005676747,0.001915294,0.0001277611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960834,0.0003465899,0.0007387015,0.00009726451,0.0003682224,0.0001560741,0.000006441384,0.000008183487,0.002195096],"genre_scores_gemma":[0.9978153,0.0001239493,0.0002130969,0.00005171481,0.0001662962,0.000003862746,0.00001033221,0.00002134047,0.001594147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02445199,"threshold_uncertainty_score":0.3586785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471905231750333,"score_gpt":0.2560508337145901,"score_spread":0.2413317813970867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}