{"id":"W2957924163","doi":"10.1159/000499899","title":"Inhibition of Pantothenate Synthetase by Analogs of β-Alanine Precursor Ineffective as an Antibacterial Strategy","year":2019,"lang":"en","type":"article","venue":"Chemotherapy","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University; University Health Network","funders":"","keywords":"Escherichia coli; Enzyme; Pseudomonas aeruginosa; Biochemistry; Bacteria; Antimicrobial; Antibacterial activity; Alanine; Growth inhibition; Chemistry; Bacterial growth; Biology; Microbiology; Amino acid; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000895444,0.0002819894,0.0001836315,0.0001367378,0.00007979702,0.0001568111,0.0002512656,0.0001979117,0.001049292],"category_scores_gemma":[0.0001090935,0.00007686779,0.0001541251,0.0001086898,0.0001285765,0.0001484126,0.000121666,0.0002691918,0.0002010948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013174,"about_ca_system_score_gemma":0.0001839171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003489998,"about_ca_topic_score_gemma":0.0008241412,"domain_scores_codex":[0.9999379,0.00001516501,0.000006626537,0.00001359846,0.00001461759,0.00001201882],"domain_scores_gemma":[0.999956,0.00001014596,0.00001472574,0.000003764329,0.000008023396,0.000007326064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002218241,0.00008631372,0.0002069644,0.0002224037,0.00001301492,0.0001211526,0.00001865729,0.0008688191,0.9920969,0.0002509465,0.00007802384,0.00581493],"study_design_scores_gemma":[0.00003225647,0.002014542,0.0007433905,0.00002323497,0.00003383855,0.0003475556,0.00001976234,0.001691162,0.9901075,0.00007922173,0.004898742,0.000008756231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811318,0.009508429,0.004084954,0.0001648556,0.00005923058,0.0000801363,0.0001975098,0.00005820868,0.004714898],"genre_scores_gemma":[0.9907497,0.003866364,0.004105872,0.00005345095,0.000008816729,0.00002720451,0.0001608481,0.000008209141,0.001019547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049292,"threshold_uncertainty_score":0.003510177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299366093200758,"score_gpt":0.2669937060926741,"score_spread":0.2540000451606665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}