{"id":"W2957924163","doi":"10.1159/000499899","title":"Inhibition of Pantothenate Synthetase by Analogs of β-Alanine Precursor Ineffective as an Antibacterial Strategy","year":2019,"lang":"en","type":"article","venue":"Chemotherapy","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University; University Health Network","funders":"","keywords":"Escherichia coli; Enzyme; Pseudomonas aeruginosa; Biochemistry; Bacteria; Antimicrobial; Antibacterial activity; Alanine; Growth inhibition; Chemistry; Bacterial growth; Biology; Microbiology; Amino acid; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000911769,0.0001467243,0.0003054446,0.0000506038,0.00001908029,0.00001389758,0.0001415034,0.00007127621,0.0006937601],"category_scores_gemma":[0.00007149905,0.0001129796,0.00009094472,0.0001625938,0.0001214462,0.0001676821,0.00001704812,0.00007796269,0.00002433093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005285976,"about_ca_system_score_gemma":0.00002399072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002775066,"about_ca_topic_score_gemma":4.536471e-7,"domain_scores_codex":[0.9989021,0.0001623998,0.0002223238,0.0003484201,0.0001825695,0.0001821553],"domain_scores_gemma":[0.9993284,0.00009935642,0.0001962613,0.0002534107,0.00003762477,0.00008494247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007537482,0.0004743586,0.0003352084,0.00003329298,0.000006577238,0.000002956758,0.0000791172,0.000004998877,0.9934712,0.00100302,0.0000719993,0.003763521],"study_design_scores_gemma":[0.001476789,0.001167614,0.005545199,0.00001739027,0.00001094236,0.000003414059,0.00001057371,0.00007290574,0.989331,0.001669202,0.0005799691,0.0001149893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975912,0.00004636474,0.00001795013,0.00004703335,0.0001307988,0.0004630452,0.0002340479,0.00003340301,0.001436178],"genre_scores_gemma":[0.9989908,0.0002017925,0.00001069813,0.0005718398,0.00004388131,0.000008027049,0.00001727847,0.00002008403,0.0001355903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00520999,"threshold_uncertainty_score":0.7596186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299366093200758,"score_gpt":0.2669937060926741,"score_spread":0.2540000451606665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}