{"id":"W2957938624","doi":"10.1534/genetics.119.302351","title":"Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of <i>Saccharomyces cerevisiae</i>","year":2019,"lang":"en","type":"article","venue":"Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; CRISPR; Genetics; Cas9; Locus (genetics); Extrachromosomal DNA; Saccharomyces cerevisiae; Genome; Ribosomal DNA; Gene; Phylogenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395976,0.0003324537,0.0001844095,0.0001896605,0.0001184842,0.0003062346,0.0002471784,0.0002513406,0.0008024161],"category_scores_gemma":[0.0002096445,0.00009549256,0.0002350771,0.0001274745,0.0001771964,0.00008178889,0.0002600064,0.0004110397,0.0002120954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002143085,"about_ca_system_score_gemma":0.0001417508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001656233,"about_ca_topic_score_gemma":0.001512035,"domain_scores_codex":[0.999791,0.00003124835,0.00004044724,0.00004289267,0.00006324596,0.00003119612],"domain_scores_gemma":[0.9997253,0.00005414365,0.00009123571,0.00004239267,0.0000301937,0.00005670148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005902233,0.00002213622,0.0003150974,0.00001502288,0.000008472666,0.00009851133,0.00001033494,0.0001782407,0.9984553,0.0000636248,0.00002648116,0.0007477141],"study_design_scores_gemma":[0.000005825037,0.0001703909,0.006163224,0.000004228317,0.00001822674,0.0002757718,0.00003703532,0.001128008,0.9913417,0.00002927768,0.000818616,0.000007863601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949803,0.0001843095,0.003051563,0.00003650935,0.00002127834,0.00001771167,0.0006700553,0.0001323541,0.0009059962],"genre_scores_gemma":[0.996105,0.00009272736,0.001789691,0.00002335477,0.000003040201,0.0000151247,0.0006550404,0.00006992503,0.001246134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001656233,"threshold_uncertainty_score":0.003293216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008621084429630724,"score_gpt":0.278574561976034,"score_spread":0.2699534775464033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}