{"id":"W2957938624","doi":"10.1534/genetics.119.302351","title":"Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of <i>Saccharomyces cerevisiae</i>","year":2019,"lang":"en","type":"article","venue":"Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; CRISPR; Genetics; Cas9; Locus (genetics); Extrachromosomal DNA; Saccharomyces cerevisiae; Genome; Ribosomal DNA; Gene; Phylogenetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325971,0.00008266335,0.0001323973,0.00002252342,0.00001683449,0.000004410736,0.0002444511,0.00006456931,0.000005163414],"category_scores_gemma":[0.00005335098,0.00005646236,0.00003857852,0.0001115425,0.0001235252,0.000001611935,0.00007007857,0.00005574543,3.92521e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004750665,"about_ca_system_score_gemma":0.00003870896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003403819,"about_ca_topic_score_gemma":0.00003481621,"domain_scores_codex":[0.9992982,0.00004473131,0.0002638593,0.0001736076,0.0001149615,0.0001046596],"domain_scores_gemma":[0.9992284,0.00002841812,0.0001522817,0.0005170979,0.00006041053,0.00001343202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007003563,0.0000145352,0.04481414,0.0001144913,0.00001310435,6.21414e-8,0.0002142173,0.000507505,0.9525281,0.0004046709,0.00004736034,0.00133487],"study_design_scores_gemma":[0.0001867046,0.0001043407,0.04053745,0.00003897024,0.00002063944,0.000006538026,0.0004461892,0.000102191,0.9561448,0.0001602792,0.002187273,0.00006469381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948762,0.003876061,0.0004985124,0.0001323855,0.00008621108,0.0002221971,0.00001508821,0.000001500299,0.0002918232],"genre_scores_gemma":[0.9984648,0.000542412,0.0008565704,0.00004376616,0.00005715672,0.000005135197,0.0000058148,0.000007597139,0.00001671724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00427669,"threshold_uncertainty_score":0.2302468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008621084429630724,"score_gpt":0.278574561976034,"score_spread":0.2699534775464033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}