{"id":"W2957981258","doi":"10.2174/1566524019666190709181726","title":"Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: a New Target for Sepsis","year":2019,"lang":"en","type":"article","venue":"Current Molecular Medicine","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondo Nacional de Desarrollo Científico y Tecnológico; Comisión Nacional de Investigación Científica y Tecnológica; Instituto Milenio en Inmunología e Inmunoterapia; Pontificia Universidad Católica de Valparaíso; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja","keywords":"Sepsis; Downregulation and upregulation; Cytokine; Medicine; Organ dysfunction; Immunology; Inflammation; Septic shock; Multiple organ dysfunction syndrome; Pharmacology; Endocrinology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069838,0.0002004585,0.0003303355,0.0001868008,0.0001127333,0.000008347501,0.00003340733,0.00009997693,0.00005558562],"category_scores_gemma":[0.0006119707,0.000169563,0.00004005879,0.0001636164,0.00006923441,0.0002092198,0.00004606974,0.0001570805,0.00000111504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005138668,"about_ca_system_score_gemma":0.00002896709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000402452,"about_ca_topic_score_gemma":0.00000153242,"domain_scores_codex":[0.9985708,0.00009628076,0.0003100823,0.0004870853,0.0002836698,0.000252077],"domain_scores_gemma":[0.9990707,0.00006197476,0.0002334367,0.0002690422,0.0000938677,0.0002710004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001883855,0.00009903432,0.007140301,0.004066993,0.000004062055,0.000003402717,0.0002610401,0.00004247131,0.9809073,0.000004230634,0.0003289873,0.005258287],"study_design_scores_gemma":[0.005399994,0.0008191256,0.03787985,0.001384642,0.000122426,0.00004577597,0.00006489601,0.001627373,0.9518343,0.0003526208,0.0002774796,0.0001914978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920985,0.001988359,0.001391823,0.001374692,0.001554311,0.001509472,0.00001448537,0.0000562616,0.00001216372],"genre_scores_gemma":[0.9992061,0.00003641046,0.0003127404,0.00002948299,0.0002149089,0.00003266611,0.00009983297,0.00002833499,0.00003956996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03073955,"threshold_uncertainty_score":0.691458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295765566803408,"score_gpt":0.271148519462718,"score_spread":0.2581908637946839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}