{"id":"W2958009397","doi":"10.1016/j.celrep.2019.07.020","title":"Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium","year":2019,"lang":"en","type":"preprint","venue":"Cell Reports","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Victoria","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Colorado Clinical and Translational Sciences Institute; National Center for Advancing Translational Sciences; American Heart Association","keywords":"PER2; Circadian rhythm; Reprogramming; Cardioprotection; Hypoxia (environmental); Cell biology; HIF1A; Biology; Ischemia; Circadian clock; Angiogenesis; Internal medicine; Endocrinology; Chemistry; Medicine; Cancer research; Biochemistry; CLOCK; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000218148,0.0003162813,0.0002341555,0.0004267124,0.000152768,0.0004221248,0.0002129889,0.000295559,0.002583717],"category_scores_gemma":[0.0001365837,0.000242008,0.0003519813,0.0001919705,0.0003153341,0.0002807354,0.0003350814,0.0008353521,0.0004248617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002792551,"about_ca_system_score_gemma":0.0002279057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000326921,"about_ca_topic_score_gemma":0.0007525714,"domain_scores_codex":[0.999848,0.00001610235,0.000009070401,0.0000495618,0.00003811788,0.000039087],"domain_scores_gemma":[0.9998239,0.000008951414,0.00006609332,0.00003017682,0.00001440646,0.00005641488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000300633,0.00001904182,0.000232532,0.00002453303,0.000008891523,0.00004891961,0.00001237744,0.00004996841,0.9966866,0.0003861314,0.0001728529,0.002057459],"study_design_scores_gemma":[0.0001047835,0.0002756325,0.04036021,0.00001900713,0.00004499512,0.000353164,0.00004529559,0.001360024,0.9503647,0.0006397921,0.00641735,0.0000150994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687793,0.003162976,0.01740528,0.0006426263,0.0003506289,0.00004351223,0.0026225,0.0007142022,0.006278899],"genre_scores_gemma":[0.9817316,0.00118918,0.005828977,0.0002805679,0.00005925764,0.0000748399,0.001140993,0.0002516256,0.009443088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002583717,"threshold_uncertainty_score":0.008643389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824808039436751,"score_gpt":0.2205605914387107,"score_spread":0.2023125110443431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}