{"id":"W2958068808","doi":"10.1186/s13059-019-1749-5","title":"Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Université de Montréal; Montreal Heart Institute","funders":"Common Fund; Institute of Genetics; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Fondation Institut de Cardiologie de Montréal; Institut de Cardiologie de Montréal; Canada Excellence Research Chairs, Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Biology; Genome-wide association study; Candidate gene; Genetics; Chromatin; Locus (genetics); Single-nucleotide polymorphism; Coronary artery disease; Gene; Bioinformatics; Internal medicine; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761383,0.0002405719,0.0005535826,0.000212729,0.00006493011,0.00000931012,0.0003139895,0.0002502613,0.0002728454],"category_scores_gemma":[0.00009538219,0.0002045652,0.0004221035,0.0002012699,0.0001567823,0.000003195719,0.0001943724,0.0001052898,0.0000809607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003570176,"about_ca_system_score_gemma":0.0001612404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002225335,"about_ca_topic_score_gemma":0.0001621011,"domain_scores_codex":[0.9982814,0.0002955284,0.0003981445,0.0005822468,0.00007093234,0.0003718169],"domain_scores_gemma":[0.9988471,0.00006146116,0.0002615429,0.0005914443,0.0001165183,0.0001219857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001345839,0.00005336933,0.221863,0.0000101021,0.001558019,0.00000338495,0.0001397859,0.000802411,0.7751353,0.00005564106,0.0001120002,0.0001323755],"study_design_scores_gemma":[0.0007149387,0.00045889,0.9750139,0.000002708292,0.0007929646,0.000006727135,0.0002728547,0.00008419518,0.01550597,0.0004169625,0.006402357,0.0003274925],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935868,0.004019665,0.0005395928,0.00006600958,0.0002696087,0.0002858635,0.000674904,0.000009118779,0.0005484148],"genre_scores_gemma":[0.9935765,0.001077811,0.0003358694,0.0003425807,0.0001280764,0.00003537633,0.002440868,0.00001964738,0.002043248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7596293,"threshold_uncertainty_score":0.8341928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004710508224828769,"score_gpt":0.2322843708069113,"score_spread":0.2275738625820825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}