{"id":"W2958070288","doi":"10.3389/fncel.2019.00355","title":"Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis","year":2019,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Microglia; Innate immune system; Immune system; Multiple sclerosis; Disease; Immunology; Neuroscience; Monocyte; Immunity; Medicine; Biology; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004786169,0.0007767558,0.001181848,0.002109723,0.0002900817,0.0009826145,0.0007464429,0.00127471,0.003146129],"category_scores_gemma":[0.0004956867,0.0001843007,0.000341583,0.001928596,0.0004347389,0.001338903,0.0008060441,0.002083192,0.002048279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005230927,"about_ca_system_score_gemma":0.0009149715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005680645,"about_ca_topic_score_gemma":0.001301912,"domain_scores_codex":[0.9998417,0.0000271101,0.00002340762,0.00002797627,0.00006049604,0.00001930428],"domain_scores_gemma":[0.999793,0.00008134632,0.00003093541,0.000006435954,0.0000577522,0.00003050254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001072852,0.00008345069,0.0001118767,0.01547297,0.00005533573,0.0001911448,0.00007881964,0.0002407887,0.003741407,0.00375799,0.04588139,0.9302775],"study_design_scores_gemma":[0.00001908417,0.00014881,0.0007422557,0.004501472,0.00008226665,0.001461672,0.00007602452,0.00006661038,0.0006014508,0.002850978,0.9894319,0.00001752303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007611245,0.9987141,0.00007917652,0.0002259182,0.0003033853,0.000002819788,0.00001063758,0.000004924663,0.0005829254],"genre_scores_gemma":[0.0004881248,0.9981095,0.0001355138,0.0002266063,0.0003428121,0.000006338052,0.0000266645,0.000001534806,0.0006629786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003146129,"threshold_uncertainty_score":0.01052487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1174438633518304,"score_gpt":0.2958130292892656,"score_spread":0.1783691659374352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}