{"id":"W2958141427","doi":"10.1261/rna.071043.119","title":"Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins","year":2019,"lang":"en","type":"article","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Lethbridge","keywords":"Pseudouridine; RNA; Biology; Small nucleolar RNA; Small nuclear RNA; Guide RNA; Ribonucleoprotein; RNA-binding protein; Cell biology; Base pair; Non-coding RNA; Biochemistry; Molecular biology; Transfer RNA; Gene; CRISPR","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001049506,0.0001948776,0.0001696731,0.00008464807,0.00008875322,0.0002746604,0.0001499447,0.0001681619,0.0006700586],"category_scores_gemma":[0.0002600143,0.000155787,0.0001634111,0.00006754456,0.0001417739,0.0001415252,0.000105452,0.0002692914,0.0002345702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184863,"about_ca_system_score_gemma":0.0001373057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006363125,"about_ca_topic_score_gemma":0.0009010694,"domain_scores_codex":[0.9998722,0.00001989787,0.000008170089,0.00003519957,0.00003521982,0.00002929434],"domain_scores_gemma":[0.99985,0.00005046838,0.00003280563,0.00001124894,0.0000199338,0.00003551717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007918581,0.00001369591,0.0003624794,0.00001953761,0.00000389025,0.00001859118,0.0000139089,0.0001057092,0.998239,0.00006423,0.00001455293,0.001065272],"study_design_scores_gemma":[0.000004315736,0.000166416,0.007962872,0.000003060657,0.000007781166,0.00005906745,0.0000200837,0.002417746,0.9887544,0.0000303788,0.0005685047,0.000005342346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972845,0.0008453723,0.001068904,0.00001431841,0.0000115252,0.000009401479,0.00004705548,0.00002170045,0.0006971013],"genre_scores_gemma":[0.9984626,0.0002846243,0.0006127536,0.00001364042,0.000004975752,0.000009728763,0.00009930154,0.00000693293,0.0005054841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006700586,"threshold_uncertainty_score":0.002241552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119118570269765,"score_gpt":0.2474249483003125,"score_spread":0.2262337625976149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}