{"id":"W2958141427","doi":"10.1261/rna.071043.119","title":"Base-pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins","year":2019,"lang":"en","type":"article","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates; University of Lethbridge","keywords":"Pseudouridine; RNA; Biology; Small nucleolar RNA; Small nuclear RNA; Guide RNA; Ribonucleoprotein; RNA-binding protein; Cell biology; Base pair; Non-coding RNA; Biochemistry; Molecular biology; Transfer RNA; Gene; CRISPR","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003513011,0.0001756756,0.0001959492,0.00004506383,0.0001448776,0.00004734178,0.0003301838,0.0001097201,0.0000333853],"category_scores_gemma":[0.00005086567,0.0001273794,0.0001077793,0.0001420686,0.0001515411,0.00001581667,0.00009524977,0.0001894616,0.000007591304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001875714,"about_ca_system_score_gemma":0.00004591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000304536,"about_ca_topic_score_gemma":0.00008888116,"domain_scores_codex":[0.9987947,0.00008957762,0.0004502019,0.0002927141,0.0001553439,0.0002175],"domain_scores_gemma":[0.9987275,0.00005999771,0.0003682859,0.0006002518,0.0001851502,0.00005880277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003014887,0.00003471053,0.004174069,0.00002966762,0.00009369121,2.328026e-7,0.00009292805,0.0004507852,0.9929807,0.0001198221,0.000263647,0.001729619],"study_design_scores_gemma":[0.0002980561,0.0001178214,0.04259593,0.00004015123,0.00006669367,0.000002863222,0.000175632,0.0005451575,0.9532229,0.000057214,0.002723798,0.0001538037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962779,0.000323095,0.0009521715,0.0006042774,0.0001015664,0.0003360868,0.0002019078,0.00001076687,0.001192268],"genre_scores_gemma":[0.9982811,0.0002553249,0.0003575143,0.00005542391,0.0001128753,0.00001462219,0.00007022975,0.00002810962,0.0008247713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0397578,"threshold_uncertainty_score":0.5194381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119118570269765,"score_gpt":0.2474249483003125,"score_spread":0.2262337625976149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}