{"id":"W2958282720","doi":"10.1111/tra.12679","title":"Biogenesis of lysosome‐related organelles complex‐1 (BORC) regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate","year":2019,"lang":"en","type":"article","venue":"Traffic","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Austrian Science Fund","keywords":"Cell biology; Endosome; Lysosome; Biology; Phosphatidylinositol; Autophagy; Golgi apparatus; Activator (genetics); Organelle biogenesis; Kinase; Organelle; Biogenesis; Biochemistry; Enzyme; Endoplasmic reticulum; Receptor; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120814,0.0002951043,0.0001984662,0.00020663,0.0002304182,0.0004725681,0.0001560179,0.0002837686,0.001024968],"category_scores_gemma":[0.0001101125,0.0001385485,0.0001887357,0.0001145674,0.0002138217,0.0002317936,0.0003709691,0.0003507613,0.00049086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008705925,"about_ca_system_score_gemma":0.0002568423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009075151,"about_ca_topic_score_gemma":0.001482651,"domain_scores_codex":[0.9998955,0.00001026363,0.000008717428,0.00003243975,0.00002307486,0.00002997086],"domain_scores_gemma":[0.9999099,0.000008787149,0.00002873775,0.000007850248,0.00001294219,0.00003172551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008069415,0.000004637577,0.0001376212,0.00001275009,0.000002028323,0.0000205332,0.000003366504,0.00003104987,0.9993224,0.00009463613,0.00003069791,0.0002596763],"study_design_scores_gemma":[0.00001938941,0.00004905715,0.01187774,0.000006922559,0.00001044527,0.0001936266,0.000022729,0.001587579,0.9835233,0.0001072042,0.002595783,0.000006255831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903936,0.002390062,0.004348776,0.0002159765,0.00004165028,0.00002296042,0.0008914612,0.000162659,0.001532802],"genre_scores_gemma":[0.993645,0.000475425,0.002134343,0.00005100096,0.000005267038,0.00001872481,0.0008243895,0.00003418789,0.002811829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024968,"threshold_uncertainty_score":0.006316543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00896016414576325,"score_gpt":0.2267187037816065,"score_spread":0.2177585396358432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}