{"id":"W2958736583","doi":"10.1039/c9mt00147f","title":"Copper relay path through the N-terminus of Wilson disease protein, ATP7B","year":2019,"lang":"en","type":"article","venue":"Metallomics","topic":"Trace Elements in Health","field":"Nursing","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Chalmers; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse","keywords":"Chaperone (clinical); Transport protein; Chemistry; Cytoplasm; C-terminus; Golgi apparatus; Docking (animal); Macromolecular docking; Biochemistry; Saccharomyces cerevisiae; Cysteine; Yeast; Menkes disease; Protein structure; Cell biology; Biophysics; Copper; Enzyme; Biology; Amino acid; Copper metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008172457,0.000172333,0.0002240676,0.0001113212,0.0002121848,0.0003352453,0.0002808601,0.0002862779,0.0009875849],"category_scores_gemma":[0.0001363847,0.0001453983,0.0001252849,0.0001157551,0.0001915898,0.0002358139,0.0002253493,0.0003089563,0.0004915993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004460946,"about_ca_system_score_gemma":0.0003408107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620985,"about_ca_topic_score_gemma":0.001558524,"domain_scores_codex":[0.9999238,0.00001229678,0.00000540217,0.00002109622,0.00002642196,0.00001098696],"domain_scores_gemma":[0.9999311,0.000009453347,0.00001804154,0.000007358245,0.00001371809,0.00002034895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107766,0.000009957461,0.0003394751,0.00003612062,0.000002852588,0.0001222396,0.00003928649,0.00007243596,0.9974291,0.0003935196,0.00007518663,0.00137215],"study_design_scores_gemma":[0.00001916646,0.0001395451,0.003594115,0.00001558454,0.00001171467,0.0005890175,0.0001125774,0.001917142,0.9863008,0.0002917164,0.007001243,0.000007387145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925969,0.0009458407,0.004917528,0.0001319709,0.00001898779,0.000008954659,0.0001447437,0.00008788587,0.001147239],"genre_scores_gemma":[0.9942139,0.0003498958,0.003211586,0.00003561046,0.000002490903,0.000008083412,0.0002262461,0.00002236463,0.001929912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620985,"threshold_uncertainty_score":0.003303826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017192428880644,"score_gpt":0.2823775805265591,"score_spread":0.2651851516459151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}