{"id":"W2958757303","doi":"10.1007/s40265-019-01169-y","title":"Innovations in Oral Therapies for Inflammatory Bowel Disease","year":2019,"lang":"en","type":"review","venue":"Drugs","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; University of Calgary","funders":"","keywords":"Medicine; Inflammatory bowel disease; Ulcerative colitis; Vedolizumab; Infliximab; Drug development; Tofacitinib; Internal medicine; Adverse effect; Pharmacology; Drug; Disease; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009288188,0.001095057,0.002150343,0.001961404,0.0002840157,0.001366153,0.0009047122,0.001359007,0.004542963],"category_scores_gemma":[0.001185056,0.0002890253,0.0006305183,0.001833944,0.0006921158,0.001422894,0.0008666806,0.003631137,0.002357854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007132857,"about_ca_system_score_gemma":0.0008729775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007262342,"about_ca_topic_score_gemma":0.001718718,"domain_scores_codex":[0.9996912,0.00007055284,0.00003794316,0.00004311945,0.0001205572,0.00003657085],"domain_scores_gemma":[0.9995058,0.0002836539,0.00006178847,0.00001606975,0.00009053147,0.00004209361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001931716,0.00009793008,0.00009926272,0.01291116,0.00008552225,0.0001913303,0.00003148163,0.0003840665,0.001571915,0.005710125,0.04665382,0.9320703],"study_design_scores_gemma":[0.00006001667,0.0001292168,0.0003239514,0.002600021,0.0001098675,0.0005831243,0.00002716912,0.0001013863,0.0002980967,0.002604672,0.9931477,0.00001481964],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004334748,0.9983523,0.0001228433,0.0003212934,0.0004048668,0.000002834971,0.00001379592,0.000006216464,0.000732451],"genre_scores_gemma":[0.0004495523,0.9976305,0.0002536854,0.0004476628,0.0005421263,0.000006859454,0.0000252655,0.000002421098,0.0006418442],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004542963,"threshold_uncertainty_score":0.01519775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02364530140684572,"score_gpt":0.3107230209837264,"score_spread":0.2870777195768807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}