{"id":"W2959088509","doi":"10.1158/1078-0432.ccr-19-0113","title":"Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Cisplatin; Medicine; Internal medicine; Single-nucleotide polymorphism; Creatinine; Oncology; Genome-wide association study; Chemotherapy; Gastroenterology; Endocrinology; Genotype; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005062244,0.0002050217,0.001190826,0.0004996252,0.00005353482,0.00002960081,0.0002202857,0.0004504787,0.008529225],"category_scores_gemma":[0.001111092,0.0001788633,0.0004856072,0.001562561,0.0007919676,0.00007196802,0.00009137456,0.001233909,0.00007188938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001260812,"about_ca_system_score_gemma":0.0007054154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008254562,"about_ca_topic_score_gemma":0.0001384395,"domain_scores_codex":[0.9957559,0.0005482091,0.001377378,0.0008136507,0.001000942,0.000503997],"domain_scores_gemma":[0.9945936,0.003282454,0.00023911,0.0008836419,0.0005911142,0.0004101335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001521986,0.0002957627,0.9691432,0.0001392823,0.0009458978,0.000009335914,0.0001398107,0.00001994913,0.006069691,0.000006556294,0.0001538459,0.0215547],"study_design_scores_gemma":[0.005150518,0.0007818951,0.9806467,0.0001276625,0.0002977024,6.828184e-7,0.00005363361,0.002196806,0.009248427,0.00006981731,0.001257546,0.0001686553],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930801,0.0003300219,0.0000940227,0.004817999,0.0001258822,0.0008749139,0.0001050744,0.00003331907,0.0005386824],"genre_scores_gemma":[0.9942189,0.0003327497,0.0007982803,0.002785421,0.0003298926,0.00003720195,0.00002064893,0.00005730523,0.001419638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02138605,"threshold_uncertainty_score":0.9923771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1559513880241714,"score_gpt":0.5000697512846275,"score_spread":0.3441183632604561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}