{"id":"W2959096163","doi":"10.1001/jamaoncol.2019.1588","title":"Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma","year":2019,"lang":"en","type":"article","venue":"JAMA Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":765,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; AstraZeneca","keywords":"Durvalumab; Medicine; Tremelimumab; Gemcitabine; Internal medicine; Population; Combination therapy; Oncology; Surgery; Cancer; Immunotherapy; Ipilimumab; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004758944,0.000356475,0.001600925,0.0002350379,0.000128957,0.00002763373,0.0002029873,0.0002343746,0.001157099],"category_scores_gemma":[0.0003592836,0.0002017207,0.000105195,0.0003297795,0.0003390003,0.0001777122,0.00005990702,0.0004048344,0.0002540074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005016271,"about_ca_system_score_gemma":0.001910985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001037177,"about_ca_topic_score_gemma":0.0001990169,"domain_scores_codex":[0.9972832,0.0002254123,0.0004774306,0.000639767,0.0005701918,0.0008040169],"domain_scores_gemma":[0.9971576,0.001068914,0.0002534012,0.000599848,0.0005828161,0.0003373625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03719622,0.001284541,0.9550898,0.0004116548,0.001004683,0.000234411,0.0005609092,0.000003173404,0.00007860424,0.0002030884,0.001238028,0.002694875],"study_design_scores_gemma":[0.06121912,0.0594485,0.8641092,0.0002388933,0.002272729,0.0008651292,0.001035669,0.002014714,0.00003810411,0.00008721192,0.008291462,0.0003792788],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849966,0.00013624,0.0005196723,0.00148014,0.0001075886,0.004414446,0.00003765801,0.00007738941,0.008230265],"genre_scores_gemma":[0.9660481,0.00003045277,0.02248543,0.000959584,0.0001626792,0.0006446024,0.0001533202,0.00008552009,0.009430312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09098063,"threshold_uncertainty_score":0.999756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03113434771125084,"score_gpt":0.3374684671745833,"score_spread":0.3063341194633324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}