{"id":"W2959132529","doi":"10.1093/annonc/mdz154.026","title":"Pembrolizumab (Pembro) therapy vs best supportive care (BSC) in advanced hepatocellular carcinoma (HCC): KEYNOTE-240","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Sorafenib; Interim analysis; Interim; Mallinckrodt; Internal medicine; Clinical trial; Family medicine; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001804704,0.0002699997,0.0009024437,0.0002916997,0.0002717607,0.001096974,0.000426044,0.000679318,0.009457824],"category_scores_gemma":[0.002255615,0.0001568301,0.001266377,0.0005787974,0.000198326,0.0009511332,0.0004754823,0.00222921,0.0006649281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046622,"about_ca_system_score_gemma":0.001427468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725205,"about_ca_topic_score_gemma":0.005899533,"domain_scores_codex":[0.9996517,0.0001699934,0.00003412261,0.00003321652,0.0000388794,0.00007216608],"domain_scores_gemma":[0.9990479,0.0005025545,0.0001210493,0.00003468888,0.00007375274,0.0002200389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2601789,0.002976787,0.01715278,0.007271368,0.004876917,0.0002187129,0.0002202682,0.001536286,0.002779165,0.003861303,0.05659539,0.6423322],"study_design_scores_gemma":[0.2276037,0.1311263,0.2407812,0.01360267,0.03182951,0.001127973,0.001242586,0.003951888,0.003431952,0.01231949,0.332721,0.0002617661],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3871145,0.4963942,0.0008992073,0.05873919,0.01409494,0.0007700325,0.004146063,0.00008056487,0.03776137],"genre_scores_gemma":[0.7462238,0.2076712,0.002189506,0.0156416,0.01226219,0.0008472483,0.002945587,0.00004900093,0.0121698],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009457824,"threshold_uncertainty_score":0.03163958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09543393774102775,"score_gpt":0.3370100366263533,"score_spread":0.2415760988853256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}