{"id":"W2959197297","doi":"10.3389/fendo.2019.00481","title":"Insulin Enhances Migration and Invasion in Prostate Cancer Cells by Up-Regulation of FOXC2","year":2019,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cancer Council Queensland; Prostate Cancer Foundation of Australia; Prostate Cancer Foundation; Cancer Australia; Department of Health and Aged Care, Australian Government; Movember Foundation; Cure Cancer Australia Foundation; Australian Government","keywords":"LNCaP; DU145; Cancer research; Prostate cancer; Hyperinsulinemia; Metastasis; Biology; Epithelial–mesenchymal transition; Cell migration; Insulin; PI3K/AKT/mTOR pathway; Androgen receptor; Cell; Cancer; Endocrinology; Internal medicine; Medicine; Signal transduction; Cell biology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179719,0.0002418214,0.0001875882,0.0002613958,0.0001899455,0.0003302913,0.00008417397,0.0001343703,0.001525205],"category_scores_gemma":[0.00006687066,0.0001043549,0.000370166,0.0002741278,0.0001586563,0.000118368,0.000146596,0.0005122389,0.000279384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774193,"about_ca_system_score_gemma":0.0003338471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002325283,"about_ca_topic_score_gemma":0.003575493,"domain_scores_codex":[0.9998746,0.00001064405,0.000008880553,0.00002669073,0.00004407916,0.00003498981],"domain_scores_gemma":[0.9999541,0.000006656509,0.000009753002,0.000004603403,0.000009096868,0.000015798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002368119,0.00007968774,0.00050746,0.00007171099,0.000008654316,0.00004055931,0.00002519848,0.00005985966,0.9960114,0.00007926314,0.0002237884,0.002655705],"study_design_scores_gemma":[0.00004945202,0.0005550287,0.03020711,0.00001285074,0.00003603136,0.0002129151,0.00007080514,0.00219765,0.9584552,0.00005390929,0.00813769,0.00001133794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882736,0.003798183,0.001793181,0.0002515892,0.00008632345,0.00003892038,0.0009355535,0.0001540744,0.004668474],"genre_scores_gemma":[0.9881989,0.002261774,0.002308333,0.0002281099,0.00002134909,0.00006437804,0.001547263,0.00003515891,0.005334854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002325283,"threshold_uncertainty_score":0.005102277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108552058456325,"score_gpt":0.2770799542778886,"score_spread":0.2662247484322561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}