{"id":"W2959197297","doi":"10.3389/fendo.2019.00481","title":"Insulin Enhances Migration and Invasion in Prostate Cancer Cells by Up-Regulation of FOXC2","year":2019,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cancer Council Queensland; Prostate Cancer Foundation of Australia; Prostate Cancer Foundation; Cancer Australia; Department of Health and Aged Care, Australian Government; Movember Foundation; Cure Cancer Australia Foundation; Australian Government","keywords":"LNCaP; DU145; Cancer research; Prostate cancer; Hyperinsulinemia; Metastasis; Biology; Epithelial–mesenchymal transition; Cell migration; Insulin; PI3K/AKT/mTOR pathway; Androgen receptor; Cell; Cancer; Endocrinology; Internal medicine; Medicine; Signal transduction; Cell biology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006646466,0.00009233636,0.000274302,0.0002665959,0.00001196658,0.000003666283,0.00004107395,0.000058453,0.00004334448],"category_scores_gemma":[0.00001201442,0.00007719682,0.00001850465,0.0001924515,0.0001009074,0.00009239004,0.00002847976,0.0001374355,0.000003430458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001328227,"about_ca_system_score_gemma":0.00007953413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008226397,"about_ca_topic_score_gemma":0.0003301515,"domain_scores_codex":[0.9991252,0.00005328649,0.0002225044,0.0002352737,0.0001143923,0.0002493746],"domain_scores_gemma":[0.9997261,0.00002266161,0.00006728502,0.0001136515,0.00003720642,0.00003305181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007915453,0.00007567532,0.7767133,0.0001326577,0.00002191796,0.000005785491,0.0007618487,0.00002621402,0.1920227,0.00001699459,0.002244402,0.02718697],"study_design_scores_gemma":[0.006461799,0.0005205442,0.2669581,0.0001815318,0.00001733316,0.000005694103,0.0007534006,0.001250944,0.7193556,0.0004566981,0.003919704,0.0001185376],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885726,0.009200434,0.00002663742,0.0008154744,0.0004844959,0.0006779386,0.00001478317,0.000009088471,0.0001985317],"genre_scores_gemma":[0.9843205,0.01342522,0.0003733842,0.00003689374,0.00001469773,0.00007236378,0.00005417355,0.000009137112,0.00169363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5273329,"threshold_uncertainty_score":0.3147995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108552058456325,"score_gpt":0.2770799542778886,"score_spread":0.2662247484322561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}