{"id":"W2959231862","doi":"10.1038/s41598-019-46832-2","title":"MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Sun Pharma; Canada Research Chairs; DUSA Pharmaceuticals; Foundation for the National Institutes of Health","keywords":"Sonodynamic therapy; Medicine; Glioma; Focused ultrasound; Ultrasound; Brain tumor; Magnetic resonance imaging; Sonication; High-intensity focused ultrasound; Nuclear medicine; Pathology; Radiology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004061474,0.0008086127,0.000456525,0.0007049812,0.0001581592,0.0002162723,0.0004573305,0.0005141802,0.0008970171],"category_scores_gemma":[0.0001388519,0.000292427,0.0004699966,0.000287301,0.000428402,0.0003088883,0.0002510218,0.0007399071,0.0003648456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004164778,"about_ca_system_score_gemma":0.0003373379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002707639,"about_ca_topic_score_gemma":0.003448273,"domain_scores_codex":[0.9997723,0.00003840294,0.0000158069,0.00005755697,0.00005765889,0.00005825338],"domain_scores_gemma":[0.9998313,0.0000165089,0.00006952488,0.00002069314,0.00002502595,0.00003687502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001653559,0.00007081157,0.00004680693,0.00002542816,0.000004278441,0.00003233949,0.00001639988,0.00009186658,0.99865,0.00003642964,0.00003172158,0.0008286538],"study_design_scores_gemma":[0.00002628467,0.002416675,0.001097265,0.000005856021,0.00003408031,0.0001462963,0.00002852814,0.001285736,0.9940499,0.00002088766,0.0008799976,0.000008437834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828052,0.002076969,0.01314248,0.0001806729,0.00007991321,0.0001247826,0.0002891841,0.0003541276,0.0009467579],"genre_scores_gemma":[0.9775155,0.00217963,0.0157337,0.00007509092,0.00002467982,0.0002130023,0.0003747494,0.00004420253,0.003839392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002707639,"threshold_uncertainty_score":0.00538379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563946071376633,"score_gpt":0.2255975233901562,"score_spread":0.2099580626763898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}