{"id":"W2959335923","doi":"10.1212/nxg.0000000000000348","title":"Genetic risk of Parkinson disease and progression:","year":2019,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Human Genome Research Institute; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; Helse Sør-Øst RHF; Medical Research Council; Parkinsonfonden; Allergan; National Institutes of Health; Voyager Therapeutics; National Institute for Health and Care Research; Agence Nationale de Sécurité du Médicament et des Produits de Santé; Centre National de la Recherche Scientifique; Evelyn Trust; Ipsen; Fonds Wetenschappelijk Onderzoek; Association France Parkinson; Assistance Publique - Hôpitaux de Paris; Institut National de la Santé et de la Recherche Médicale; Biogen; Agence Nationale de la Recherche; H. Lundbeck A/S; Rosetrees Trust; Parkinson's UK; Radboud Universiteit; Hersenstichting; Verily Life Sciences; GlaxoSmithKline; Barts Charity; Johns Hopkins University; Amarin Corporation; Michael J. Fox Foundation for Parkinson's Research; Parkinson's Foundation; Kinetics Foundation; Wellcome Trust; ZonMw; Britannia Pharmaceuticals; Weston Brain Institute; National Institute of Neurological Disorders and Stroke; Sunovion; Norges Forskningsråd; University of Virginia; National Parkinson Foundation; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; University of Rochester; University of Pennsylvania; Brown University; CHDI Foundation; Massachusetts General Hospital; Smart Family Foundation; Parkinson's Disease Foundation; U.S. Department of Defense; Ohio State University; Harvard NeuroDiscovery Center; Parkinson Vereniging; Nasjonalforeningen for Folkehelsen; University of Michigan","keywords":"Allele; Odds ratio; Hazard ratio; LRRK2; Genotype; Internal medicine; Disease; Genetics; Medicine; Biology; Parkinson's disease; Confidence interval; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003803486,0.0003012211,0.0002755141,0.0002958138,0.000244071,0.0003653996,0.0002066584,0.000723317,0.00252441],"category_scores_gemma":[0.0009466841,0.0001007791,0.0005944261,0.0004514724,0.0001765838,0.0002248627,0.0002734003,0.000594799,0.0001321072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688885,"about_ca_system_score_gemma":0.0002989675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005706221,"about_ca_topic_score_gemma":0.007218251,"domain_scores_codex":[0.9997891,0.00005256212,0.00001314479,0.00006784304,0.00004044442,0.00003705932],"domain_scores_gemma":[0.999612,0.00006418335,0.0001648317,0.00002822515,0.00003677009,0.0000939155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007958908,0.00005968102,0.9877082,0.00003833047,0.0003882824,0.000303272,0.00005212674,0.0002126127,0.001728796,0.00008864808,0.0004297296,0.008194309],"study_design_scores_gemma":[0.000024868,0.0001246541,0.9983089,0.00001274374,0.0000968421,0.0003894054,0.00002318811,0.000422533,0.0001463983,0.000140191,0.0003064874,0.000003792661],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962133,0.001065681,0.0004649284,0.0002455837,0.00001958501,0.00001842197,0.0008025003,0.00001485941,0.001155141],"genre_scores_gemma":[0.9985348,0.0002101706,0.0002786558,0.00007539139,0.00003395354,0.000009991151,0.0003908921,0.000003440733,0.0004627415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005706221,"threshold_uncertainty_score":0.01134604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009533747352843087,"score_gpt":0.2584193033352295,"score_spread":0.2488855559823864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}