{"id":"W2959335923","doi":"10.1212/nxg.0000000000000348","title":"Genetic risk of Parkinson disease and progression:","year":2019,"lang":"en","type":"article","venue":"Neurology Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Human Genome Research Institute; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; Helse Sør-Øst RHF; Medical Research Council; Parkinsonfonden; Allergan; National Institutes of Health; Voyager Therapeutics; National Institute for Health and Care Research; Agence Nationale de Sécurité du Médicament et des Produits de Santé; Centre National de la Recherche Scientifique; Evelyn Trust; Ipsen; Fonds Wetenschappelijk Onderzoek; Association France Parkinson; Assistance Publique - Hôpitaux de Paris; Institut National de la Santé et de la Recherche Médicale; Biogen; Agence Nationale de la Recherche; H. Lundbeck A/S; Rosetrees Trust; Parkinson's UK; Radboud Universiteit; Hersenstichting; Verily Life Sciences; GlaxoSmithKline; Barts Charity; Johns Hopkins University; Amarin Corporation; Michael J. Fox Foundation for Parkinson's Research; Parkinson's Foundation; Kinetics Foundation; Wellcome Trust; ZonMw; Britannia Pharmaceuticals; Weston Brain Institute; National Institute of Neurological Disorders and Stroke; Sunovion; Norges Forskningsråd; University of Virginia; National Parkinson Foundation; EU Joint Programme – Neurodegenerative Disease Research; Pfizer; University of Rochester; University of Pennsylvania; Brown University; CHDI Foundation; Massachusetts General Hospital; Smart Family Foundation; Parkinson's Disease Foundation; U.S. Department of Defense; Ohio State University; Harvard NeuroDiscovery Center; Parkinson Vereniging; Nasjonalforeningen for Folkehelsen; University of Michigan","keywords":"Allele; Odds ratio; Hazard ratio; LRRK2; Genotype; Internal medicine; Disease; Genetics; Medicine; Biology; Parkinson's disease; Confidence interval; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000399658,0.0001306268,0.0002220067,0.00006004684,0.00002929664,0.000003827086,0.00005067338,0.00008103048,0.00009041501],"category_scores_gemma":[0.00002219591,0.0001065747,0.00005741978,0.00006260615,0.00007448377,0.00000989864,0.00005814785,0.0001051542,0.00003686409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003925469,"about_ca_system_score_gemma":0.00005502444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002796464,"about_ca_topic_score_gemma":0.00000108598,"domain_scores_codex":[0.9991081,0.00006852088,0.0001626217,0.0003185484,0.0001564112,0.0001857721],"domain_scores_gemma":[0.9992335,0.00003218546,0.0001001792,0.000349295,0.00003882657,0.0002459718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005703158,0.0002026076,0.9820836,0.00006413426,0.00007144228,0.0001480634,0.00001882616,0.000019848,0.001161443,0.00002174428,0.00004807342,0.01558996],"study_design_scores_gemma":[0.001654133,0.001306651,0.9779633,0.00001454886,0.0003964764,0.00003756811,0.000002070814,0.001264355,0.0009549067,0.0003892212,0.01594434,0.00007241272],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941793,0.004698636,0.00002745085,0.0002030096,0.0001608899,0.0004519671,0.00002889145,0.00002334139,0.000226491],"genre_scores_gemma":[0.9962157,0.001838533,0.001356017,0.0004188481,0.00004811673,0.00001870322,0.000007103656,0.00002130886,0.00007568801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01589627,"threshold_uncertainty_score":0.434599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009533747352843087,"score_gpt":0.2584193033352295,"score_spread":0.2488855559823864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}