{"id":"W2959401532","doi":"10.1093/brain/awz190","title":"High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Deutsche Forschungsgemeinschaft; Biogen Idec; Teva Pharmaceutical Industries; Novartis; Roche; National Institute of Neurological Disorders and Stroke; Merck; National Multiple Sclerosis Society","keywords":"Vitamin D and neurology; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Autoimmunity; Medicine; Exacerbation; Central nervous system; Excitatory postsynaptic potential; Encephalomyelitis; Endocrinology; Calcium; Internal medicine; Immunology; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009628064,0.0002410762,0.0002900662,0.0002975221,0.0001499782,0.0002898039,0.0001455124,0.0003573552,0.001512486],"category_scores_gemma":[0.0001519536,0.0001167524,0.0001896467,0.000141147,0.000245311,0.0001387677,0.0002351856,0.0005718136,0.0001989279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167999,"about_ca_system_score_gemma":0.0002056514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000502775,"about_ca_topic_score_gemma":0.001327059,"domain_scores_codex":[0.9998379,0.00003537443,0.00001889146,0.00003219174,0.00003233173,0.00004345489],"domain_scores_gemma":[0.9998827,0.0000154314,0.00003086852,0.00001254299,0.00001192514,0.00004654411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001907762,0.000219569,0.002481609,0.0001312964,0.0000385794,0.0001829302,0.00003325822,0.00003994761,0.9895978,0.00005020243,0.00009893004,0.005218009],"study_design_scores_gemma":[0.0004403217,0.01271524,0.09385163,0.00008054495,0.000342939,0.00186352,0.0003495564,0.0006588325,0.8806907,0.0004296253,0.00855272,0.00002431487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996179,0.002360565,0.0003524506,0.0001295674,0.0000321439,0.00001405126,0.0001199282,0.00003552733,0.0007767883],"genre_scores_gemma":[0.9972575,0.0009344296,0.0003948531,0.00006467326,0.00001674408,0.00001772338,0.0001112933,0.000005937291,0.00119678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512486,"threshold_uncertainty_score":0.005059838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717961176622951,"score_gpt":0.2726623809358115,"score_spread":0.255482769169582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}