{"id":"W2959492986","doi":"10.3389/fmed.2019.00170","title":"Novel Microbial-Based Immunotherapy Approach for Crohn's Disease","year":2019,"lang":"en","type":"article","venue":"Frontiers in Medicine","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McMaster University; University of Calgary; Canadian Society of Intestinal Research; Population Health Research Institute; University of Alberta; BC Cancer Agency; Simon Fraser University; University of British Columbia","funders":"Genome British Columbia","keywords":"Medicine; Tolerability; Placebo; Internal medicine; Immunotherapy; Crohn's disease; Biomarker; Immune system; Clinical endpoint; Clinical trial; Adverse effect; Disease; Randomized controlled trial; Oncology; Immunology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493164,0.0002496392,0.0003794077,0.0002048586,0.0001155284,0.0002882885,0.0002420073,0.0003362984,0.001377653],"category_scores_gemma":[0.0001141754,0.00006597779,0.0003096625,0.0001396619,0.0001944474,0.0001880789,0.0002091499,0.0006933626,0.0002576156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938546,"about_ca_system_score_gemma":0.0002163699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000139311,"about_ca_topic_score_gemma":0.0004676997,"domain_scores_codex":[0.9999253,0.00002109336,0.000004398655,0.00001435235,0.00001775517,0.00001718106],"domain_scores_gemma":[0.9999551,0.000009316139,0.00001306675,0.000003147462,0.000007232859,0.0000121192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007145473,0.00514785,0.004048518,0.002790482,0.0002420587,0.0008350527,0.0001349685,0.001297581,0.5805438,0.002334128,0.002649876,0.3928302],"study_design_scores_gemma":[0.02465614,0.2400299,0.05437413,0.001819743,0.001578621,0.01570648,0.0003159246,0.01393228,0.3969338,0.00510874,0.2454133,0.0001309731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.826803,0.1540449,0.01003569,0.001433881,0.0007502321,0.0006371431,0.0002646047,0.000140158,0.005890341],"genre_scores_gemma":[0.9451272,0.038314,0.01120826,0.0009861203,0.0003992041,0.0004819311,0.00033781,0.000008240223,0.003137215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377653,"threshold_uncertainty_score":0.004608691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006511748765425106,"score_gpt":0.2305329870025617,"score_spread":0.2240212382371366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}