{"id":"W2959755773","doi":"10.1016/j.jmb.2019.07.019","title":"Non-catalytic Binding Sites Induce Weaker Long-Range Evolutionary Rate Gradients than Catalytic Sites in Enzymes","year":2019,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Allosteric regulation; Enzyme; Binding site; Allosteric enzyme; Catalysis; Function (biology); Ligand (biochemistry); Chemistry; Biology; Biochemistry; Biophysics; Evolutionary biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006496484,0.0002594218,0.0005470161,0.0004106737,0.0003823052,0.0009892781,0.000419111,0.0006418197,0.00217614],"category_scores_gemma":[0.001536272,0.0005385687,0.0002683025,0.000300731,0.0005327097,0.0006708452,0.0005686773,0.0009531521,0.0005638121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172843,"about_ca_system_score_gemma":0.0002248048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004996287,"about_ca_topic_score_gemma":0.0009833631,"domain_scores_codex":[0.999701,0.00005875974,0.00002498044,0.00007653387,0.00007454254,0.00006417199],"domain_scores_gemma":[0.9987619,0.0004444255,0.0001803687,0.0001736358,0.0001562832,0.0002833348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004977507,0.0001007442,0.007075442,0.00007740095,0.0000601685,0.00007992247,0.00005850342,0.001451821,0.9817609,0.002590867,0.0001082426,0.006138232],"study_design_scores_gemma":[0.0001681062,0.0006501075,0.2367172,0.00002598246,0.0001389291,0.001151544,0.0002885155,0.03417295,0.7153739,0.008675283,0.002536221,0.0001012493],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962019,0.0002207832,0.002748783,0.00005116801,0.00001310244,0.000006128007,0.00003278993,0.00003295454,0.0006924348],"genre_scores_gemma":[0.9986261,0.0000581497,0.0007729139,0.00004694431,0.000007815094,0.000005134712,0.00005478702,0.00002451576,0.0004035183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217614,"threshold_uncertainty_score":0.007279873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006888824761117212,"score_gpt":0.2470693012336232,"score_spread":0.240180476472506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}