{"id":"W2960015172","doi":"10.1186/s12974-019-1538-9","title":"Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway","year":2019,"lang":"en","type":"review","venue":"Journal of Neuroinflammation","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Università degli Studi di Padova; Nvidia","keywords":"Microglia; Neuroinflammation; TLR4; Chemistry; Pharmacology; Signal transduction; Inflammation; Biochemistry; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002957904,0.000793089,0.002421843,0.001387366,0.0002304879,0.0001153972,0.0005595027,0.001024405,0.0001301114],"category_scores_gemma":[0.0007657885,0.0006507363,0.0008532421,0.0003552994,0.0001868946,0.0008040424,0.0001974844,0.001672755,0.001344187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266364,"about_ca_system_score_gemma":0.0008670914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003246107,"about_ca_topic_score_gemma":0.000001491903,"domain_scores_codex":[0.9926023,0.003166991,0.002966104,0.0004878098,0.0002159716,0.0005608516],"domain_scores_gemma":[0.9935252,0.001153453,0.004127423,0.0006976858,0.0004178384,0.0000783634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001550649,0.00004615036,0.000007776574,0.004233001,0.0004636161,0.0001507019,0.0003383697,0.000005212024,0.3879454,0.00004820557,0.00120519,0.6040057],"study_design_scores_gemma":[0.001521937,0.0006473315,0.0002032385,0.005557867,0.0007490694,0.003022104,0.00003980443,0.000006382974,0.02226236,0.00004764652,0.9653323,0.0006099066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1002115,0.896138,0.0001006171,0.0001812467,0.00215745,0.001035074,0.00002334192,0.00005229343,0.0001004833],"genre_scores_gemma":[0.001292714,0.995128,0.00006554493,0.00002680004,0.000306856,0.00002262298,0.0001276378,0.0001316738,0.002898163],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9641272,"threshold_uncertainty_score":0.9995944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186677744855996,"score_gpt":0.2830528611925863,"score_spread":0.2511860837440263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}