{"id":"W2960149900","doi":"10.1038/s41598-019-46306-5","title":"A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); Genome British Columbia; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates Bio Solutions; Consortium canadien en neurodégénérescence associée au vieillissement; Western Canada Research Grid; Compute Canada; Government of Canada; Alberta Prion Research Institute; Fondation Brain Canada","keywords":"Antibody; Epitope; Monoclonal antibody; Potency; In vivo; Humanized antibody; Pharmacology; Toxicity; In vitro; Pathogenesis; Alzheimer's disease; Adverse effect; Chemistry; Amyloid beta; Medicine; Immunology; Disease; Biochemistry; Biology; Peptide; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135758,0.0004372263,0.0002149129,0.0001043263,0.0001086526,0.0002254447,0.0003575423,0.0003490642,0.001115926],"category_scores_gemma":[0.0001853098,0.0001257863,0.0001697227,0.00009217874,0.0002225188,0.0001859029,0.00018219,0.0005026464,0.000367479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004384241,"about_ca_system_score_gemma":0.0005615539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008287036,"about_ca_topic_score_gemma":0.001004137,"domain_scores_codex":[0.9998989,0.0000187368,0.00000507591,0.00002582201,0.00002582454,0.00002558172],"domain_scores_gemma":[0.9999646,0.0000052809,0.000008563706,0.000003203895,0.000008190481,0.00001011195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003446372,0.0002812514,0.0003355386,0.0001328164,0.00002087345,0.0002588266,0.00002728174,0.002454862,0.9750151,0.001852954,0.0008981492,0.01837762],"study_design_scores_gemma":[0.0005017667,0.002295832,0.0011888,0.00001917269,0.000073717,0.001366321,0.00001720306,0.009871799,0.9604009,0.0004623909,0.02378138,0.00002073438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9191647,0.004451101,0.06478128,0.000776752,0.0002828592,0.0005125671,0.0005043164,0.0003730157,0.009153663],"genre_scores_gemma":[0.9551331,0.001958345,0.03666631,0.0004018821,0.00002748868,0.000168093,0.0005971158,0.00002447705,0.005023352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115926,"threshold_uncertainty_score":0.003733099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074652252879619,"score_gpt":0.339433042099051,"score_spread":0.3086865195702548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}