{"id":"W2960300103","doi":"10.1371/journal.ppat.1007864","title":"Full atomistic model of prion structure and conversion","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; Fondazione Telethon; European Commission","keywords":"Scrapie; Prion protein; Biophysics; Chemistry; Solenoid; Protein folding; Protein structure; Molecular dynamics; Gene isoform; Folding (DSP implementation); Computational biology; Crystallography; Biology; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002691451,0.0007946017,0.001061494,0.0005202943,0.0008605422,0.001074483,0.002847265,0.002565429,0.007100475],"category_scores_gemma":[0.0009236922,0.0004531471,0.0009394523,0.0006722375,0.001363018,0.001292756,0.001007857,0.001198686,0.00116529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001446091,"about_ca_system_score_gemma":0.001283875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01400211,"about_ca_topic_score_gemma":0.004067616,"domain_scores_codex":[0.9998227,0.00004419321,0.000007024958,0.00002912031,0.00006962933,0.0000273499],"domain_scores_gemma":[0.9997731,0.00007458198,0.000022811,0.0000378249,0.00004511283,0.00004654601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006388575,0.0000501787,0.0004508091,0.00006986857,0.00003326036,0.0002988886,0.00006674692,0.9508544,0.002090249,0.0428254,0.001191859,0.002004424],"study_design_scores_gemma":[0.00002945367,0.00001802601,0.0001872799,0.000006498355,0.000008101862,0.00004643144,0.00001208532,0.9838927,0.0001104271,0.01424429,0.001433481,0.00001134422],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4308602,0.003883346,0.3569033,0.004346485,0.0006179575,0.0003889554,0.007905719,0.00140554,0.1936886],"genre_scores_gemma":[0.9368469,0.001667685,0.03600179,0.0005067024,0.0001520284,0.0008668379,0.001764788,0.0001974199,0.02199589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01400211,"threshold_uncertainty_score":0.02784121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007831536953588618,"score_gpt":0.203973744413494,"score_spread":0.1961422074599053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}