{"id":"W2960530550","doi":"10.1038/s41598-019-46279-5","title":"The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Ubiquitin ligase; Ubiquitin; Proteasome; DNA ligase; Protein subunit; Biology; Immunoprecipitation; Cell biology; Ubiquitin-conjugating enzyme; Ubiquitin-Protein Ligases; Protein degradation; Molecular biology; Biochemistry; Enzyme; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001716992,0.0001811809,0.0001407439,0.00005144668,0.0005832227,0.0003409038,0.0002784633,0.0001279772,0.0002161549],"category_scores_gemma":[0.0001334237,0.0001413394,0.0001366307,0.000128375,0.0001263742,0.00001879375,0.0001069785,0.00007673362,0.00006832409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001561461,"about_ca_system_score_gemma":0.0001450027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001319628,"about_ca_topic_score_gemma":0.00007807517,"domain_scores_codex":[0.9980269,0.00008005735,0.0003544042,0.0007943058,0.0003165358,0.000427807],"domain_scores_gemma":[0.9981775,0.00002086901,0.0002885528,0.001075702,0.0002858097,0.0001516023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004760715,0.00005054748,0.00157088,0.00003854983,0.00001763865,0.00001088554,0.0001555718,0.00000853814,0.9642439,0.0001375656,0.02916624,0.004552105],"study_design_scores_gemma":[0.0001376923,0.0001035263,0.0004250208,0.000007700637,0.000007715169,0.0000417427,0.0001215161,0.0001867671,0.6202939,0.000681195,0.3778504,0.0001427934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936376,0.0004396685,0.0002986227,0.0004590219,0.002447502,0.001078564,0.00005517212,0.00002867824,0.001555138],"genre_scores_gemma":[0.9759799,0.0000164051,0.0005923004,0.0002632682,0.0001961788,0.00009449098,0.001408014,0.00002916871,0.02142028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3486842,"threshold_uncertainty_score":0.5763652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04225391743784802,"score_gpt":0.2788110687863259,"score_spread":0.2365571513484779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}