{"id":"W2960530550","doi":"10.1038/s41598-019-46279-5","title":"The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Ubiquitin ligase; Ubiquitin; Proteasome; DNA ligase; Protein subunit; Biology; Immunoprecipitation; Cell biology; Ubiquitin-conjugating enzyme; Ubiquitin-Protein Ligases; Protein degradation; Molecular biology; Biochemistry; Enzyme; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109789,0.0002832688,0.0001581362,0.0001634039,0.0002043576,0.0003401348,0.0001186178,0.0001728879,0.001394507],"category_scores_gemma":[0.00007950831,0.00006558273,0.0002036385,0.0001449825,0.0001342841,0.0001689931,0.0002189455,0.0001782201,0.0006697637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005732127,"about_ca_system_score_gemma":0.0001863302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004771604,"about_ca_topic_score_gemma":0.0008771619,"domain_scores_codex":[0.9999211,0.000008028871,0.000006806962,0.00002709034,0.00002261178,0.00001431462],"domain_scores_gemma":[0.9999559,0.00000378248,0.00001306814,0.000006496354,0.000008420338,0.00001229163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007850198,0.00001595712,0.001590408,0.00008253373,0.00001607845,0.0001460174,0.00001141112,0.0001019874,0.9923962,0.0003452724,0.000152255,0.005063271],"study_design_scores_gemma":[0.000008459277,0.00006560258,0.01414812,0.000005736582,0.00001480216,0.0007427676,0.00002861949,0.00106328,0.9723685,0.000157487,0.01138971,0.000006886046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750734,0.008423191,0.01124675,0.0002399267,0.00005400016,0.00003094127,0.000823811,0.0002534561,0.003854407],"genre_scores_gemma":[0.9856491,0.001364264,0.005280694,0.00005832708,0.00001098956,0.00001227549,0.001325848,0.00001772285,0.006280603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394507,"threshold_uncertainty_score":0.004665077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04225391743784802,"score_gpt":0.2788110687863259,"score_spread":0.2365571513484779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}