{"id":"W2960665048","doi":"10.1210/en.2019-00281","title":"Ancestral Fluoxetine Exposure Sensitizes Zebrafish to Venlafaxine-Induced Reductions in Cortisol and Spawning","year":2019,"lang":"en","type":"article","venue":"Endocrinology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Fluoxetine; Venlafaxine; Ven; Offspring; Zebrafish; Endocrinology; Serotonin; Internal medicine; Antidepressant; Physiology; Monoamine neurotransmitter; Hydrocortisone; Pregnancy; Medicine; Biology; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004961857,0.0002458312,0.0002245604,0.0001382721,0.0002009352,0.0001411034,0.0002060713,0.0003593255,0.002213097],"category_scores_gemma":[0.0001047836,0.0001451911,0.00037103,0.00005470079,0.0002612152,0.0001237029,0.0002753933,0.0006695568,0.00021743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005534086,"about_ca_system_score_gemma":0.0003328222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007409415,"about_ca_topic_score_gemma":0.02397796,"domain_scores_codex":[0.9999043,0.000006410145,0.000007303753,0.00002954696,0.0000242256,0.0000283005],"domain_scores_gemma":[0.9999497,0.000005934431,0.00001575789,0.000005846484,0.00000880347,0.00001400956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403935,0.00002015355,0.0006153663,0.00003498489,0.000006235841,0.000134304,0.0000489932,0.00003794073,0.9976872,0.00004465533,0.0001477133,0.001082139],"study_design_scores_gemma":[0.00006288228,0.002847604,0.09532955,0.0000408472,0.00006775575,0.0005001705,0.0003193881,0.0008483208,0.8920685,0.0001502979,0.007722554,0.0000421881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949408,0.0005006028,0.0009117858,0.0002328694,0.00005541662,0.0000544455,0.001117118,0.00007326477,0.002113811],"genre_scores_gemma":[0.9907392,0.0005015899,0.001096812,0.0003279374,0.00001006377,0.0001191213,0.0008225614,0.0000175314,0.006365152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007409415,"threshold_uncertainty_score":0.0147326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0269897291579903,"score_gpt":0.3020800678108959,"score_spread":0.2750903386529056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}