{"id":"W2960739547","doi":"10.1038/s41598-019-46639-1","title":"Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Agenzia Italiana del Farmaco, Ministero della Salute; Canadian Institutes of Health Research; University of California, San Francisco; University of North Carolina at Chapel Hill; Fondazione per la Ricerca sulla Fibrosi Cistica; Ministero della Salute; Cystic Fibrosis Canada; McGill University; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation; Fondazione Telethon; E-Rare; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada","keywords":"Cysteamine; Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Autophagy; Thymosin; Mutant; Chemistry; Medicine; Biochemistry; Pharmacology; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000228861,0.0001939045,0.0002424769,0.0001125188,0.000121888,0.0003148979,0.0001691746,0.0002980266,0.00159444],"category_scores_gemma":[0.0003697618,0.00006311757,0.0001297808,0.00008674142,0.000257793,0.0002035682,0.0001401908,0.0004931075,0.0003007172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368812,"about_ca_system_score_gemma":0.0002051418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000412566,"about_ca_topic_score_gemma":0.0003848598,"domain_scores_codex":[0.9997727,0.00005315674,0.0000249782,0.00004528808,0.00005230718,0.00005148833],"domain_scores_gemma":[0.9996425,0.0001371382,0.00005691967,0.00003165266,0.00005063149,0.000081098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009197897,0.000102464,0.0001631892,0.00003684777,0.000004478112,0.00006366414,0.0000333151,0.0000327044,0.9967789,0.00003785788,0.0000437935,0.001782939],"study_design_scores_gemma":[0.00005509171,0.001337184,0.001670559,0.000006975248,0.00001219568,0.0001298244,0.00004078317,0.0003364684,0.994753,0.00003288594,0.001621458,0.000003483833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977177,0.000896935,0.0003029167,0.00006891164,0.00004448014,0.00001516684,0.0001503252,0.00002002366,0.0007834492],"genre_scores_gemma":[0.9980459,0.000309249,0.0003804963,0.00003829801,0.00001120334,0.00001266033,0.000220583,0.00001127952,0.000970379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159444,"threshold_uncertainty_score":0.00533396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009686555067116054,"score_gpt":0.294019419687461,"score_spread":0.2843328646203449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}