{"id":"W2961020354","doi":"10.1093/ijnp/pyz039","title":"Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)","year":2019,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Treatment of Major Depression","field":"Medicine","cited_by":590,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa","funders":"Janssen Research and Development","keywords":"Antidepressant; Depression (economics); Double blind; Medicine; Nasal spray; Treatment-resistant depression; Safety profile; Nasal administration; Randomized controlled trial; Anesthesia; Pharmacology; Adverse effect; Internal medicine; Psychiatry; Placebo; Anxiety; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004042293,0.001615034,0.004001293,0.000654458,0.0004502842,0.00100449,0.001482497,0.002084715,0.003702555],"category_scores_gemma":[0.003106434,0.000844568,0.00279415,0.0006297532,0.00202715,0.001255699,0.0004172655,0.002469692,0.0006709427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008137926,"about_ca_system_score_gemma":0.001502423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173031,"about_ca_topic_score_gemma":0.002101421,"domain_scores_codex":[0.9980562,0.001171642,0.0001614098,0.0002546339,0.0001955669,0.000160516],"domain_scores_gemma":[0.9974883,0.0007268021,0.0007504076,0.0003055159,0.0002315402,0.0004974861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9612088,0.01862982,0.0007933285,0.0004483858,0.0009196489,0.00003150941,0.00006291688,0.0001295203,0.00616425,0.0000324844,0.0002044854,0.01137487],"study_design_scores_gemma":[0.8561149,0.1401579,0.002322352,0.00001548571,0.0004785612,0.0000253673,0.00001457458,0.0001618455,0.0005535202,0.00002182789,0.0001217887,0.00001189711],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950134,0.001621859,0.0004630386,0.0001628543,0.0001247548,0.001748653,0.0004419222,0.00006347409,0.0003599404],"genre_scores_gemma":[0.9906682,0.00208744,0.002177272,0.0004606206,0.0004360147,0.002561094,0.0007980134,0.00003358167,0.0007776232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004042293,"threshold_uncertainty_score":0.02137798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239287118790476,"score_gpt":0.3367741322409324,"score_spread":0.3143812610530276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}