{"id":"W2961100600","doi":"10.1101/708180","title":"Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Engineering and Physical Sciences Research Council; National Institutes of Health; Biotechnology and Biological Sciences Research Council; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; Horizon 2020 Framework Programme; University of Wollongong; Association Belge contre les Maladies Neuro-Musculaires","keywords":"Hsp27; HEK 293 cells; Plasma protein binding; Mutation; Binding site; Structural motif; Motif (music); Heat shock protein; Protein structure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000656602,0.0003901837,0.0001840009,0.0001700286,0.0001370583,0.0001606348,0.0001481233,0.0002178672,0.0009046923],"category_scores_gemma":[0.00008775979,0.00008988867,0.0001548356,0.0001206473,0.0001602341,0.00008086339,0.0002813742,0.0002830971,0.0002695377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509895,"about_ca_system_score_gemma":0.0001070445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000532875,"about_ca_topic_score_gemma":0.0004539618,"domain_scores_codex":[0.9999092,0.00001710802,0.000007946188,0.00002628127,0.0000200834,0.00001939777],"domain_scores_gemma":[0.9999359,0.000005863847,0.0000265429,0.000004674755,0.000003887271,0.00002311777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353516,0.00002014258,0.0008886004,0.00001538736,0.00001118152,0.0008440966,0.00001287975,0.00009785629,0.9972937,0.00005088947,0.0000829215,0.0005470632],"study_design_scores_gemma":[0.00005012654,0.0003393961,0.05989457,0.00001488607,0.00004599089,0.006469809,0.00008140284,0.003470408,0.9268824,0.0001511752,0.002583366,0.0000164086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985825,0.0001965992,0.0006878994,0.00002064288,0.000008387581,0.000006764427,0.0001589888,0.00004485066,0.0002934848],"genre_scores_gemma":[0.9987042,0.0001116019,0.000454001,0.00002985846,0.000004407947,0.00001129841,0.0002006761,0.00001341343,0.0004704497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009046923,"threshold_uncertainty_score":0.003026426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501934074060449,"score_gpt":0.2601507624646512,"score_spread":0.2451314217240468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}