{"id":"W2961103529","doi":"10.1097/pai.0000000000000794","title":"Simplified Molecular Subtyping of Medulloblastoma for Reduced Cost and Improved Turnaround Time","year":2019,"lang":"en","type":"article","venue":"Applied immunohistochemistry & molecular morphology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Subtyping; Immunohistochemistry; Medulloblastoma; Turnaround time; Immunostaining; Exon; Wnt signaling pathway; Biology; Mutation; Medicine; Internal medicine; Bioinformatics; Molecular biology; Oncology; Cancer research; Pathology; Genetics; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000150088,0.0003617241,0.0007674826,0.00009595782,0.00005710885,0.00001480077,0.0001682122,0.0002999313,0.0001337353],"category_scores_gemma":[0.00007768331,0.0003689807,0.0002190026,0.000153138,0.0002084521,0.00002298328,0.0001094769,0.0001980969,0.00003007237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632619,"about_ca_system_score_gemma":0.0001215913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002438627,"about_ca_topic_score_gemma":2.381942e-8,"domain_scores_codex":[0.9981886,0.00001863128,0.0004938685,0.0006572084,0.0001737689,0.0004679243],"domain_scores_gemma":[0.9985046,0.0001087545,0.0002823176,0.00079084,0.0001528531,0.0001605764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007797059,0.0002602436,0.00007610225,0.0002283833,0.0004026933,0.00008452585,0.0000461683,0.00001274547,0.996474,0.0005135176,0.0001222969,0.000999662],"study_design_scores_gemma":[0.005621202,0.000387589,0.0004977874,0.00006032795,0.0003586588,0.0003648082,0.00005327925,0.0001539611,0.9917896,0.0002116476,0.0002137649,0.0002873055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943275,0.001137957,0.0004721643,0.0003072272,0.00008130831,0.001909848,0.00003559841,0.00004941488,0.001678988],"genre_scores_gemma":[0.9959468,0.00001602057,0.002541264,0.0004405712,0.00002021523,0.0004868281,0.0003059198,0.00007524938,0.0001670797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004841496,"threshold_uncertainty_score":0.9998762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005185000126348081,"score_gpt":0.2486425482427974,"score_spread":0.2434575481164493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}